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pubmed-article:9846527pubmed:abstractTextCombined treatment of allograft recipients with anti-CD40 ligand and CTLA-4Ig (costimulation blockade) is a powerful promising albeit not consistently tolerizing therapy. It would be desirable to use an effective conventional immunosuppressive regimen in low doses or for a short course as an adjunct; however, cyclosporine treatment drastically blunts the ability of costimulation blockade to produce long-term engraftment.lld:pubmed
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pubmed-article:9846527pubmed:articleTitleCombined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment.lld:pubmed
pubmed-article:9846527pubmed:affiliationDepartment of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.lld:pubmed
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