rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
10
|
pubmed:dateCreated |
1998-12-29
|
pubmed:abstractText |
Combined treatment of allograft recipients with anti-CD40 ligand and CTLA-4Ig (costimulation blockade) is a powerful promising albeit not consistently tolerizing therapy. It would be desirable to use an effective conventional immunosuppressive regimen in low doses or for a short course as an adjunct; however, cyclosporine treatment drastically blunts the ability of costimulation blockade to produce long-term engraftment.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Ctla4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Sirolimus,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
|
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0041-1337
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
27
|
pubmed:volume |
66
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1387-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:9846527-Animals,
pubmed-meshheading:9846527-Antigens, CD,
pubmed-meshheading:9846527-Antigens, Differentiation,
pubmed-meshheading:9846527-CTLA-4 Antigen,
pubmed-meshheading:9846527-Drug Therapy, Combination,
pubmed-meshheading:9846527-Graft Rejection,
pubmed-meshheading:9846527-Heart Transplantation,
pubmed-meshheading:9846527-Immune Tolerance,
pubmed-meshheading:9846527-Immunoconjugates,
pubmed-meshheading:9846527-Immunosuppressive Agents,
pubmed-meshheading:9846527-Male,
pubmed-meshheading:9846527-Mice,
pubmed-meshheading:9846527-Mice, Inbred BALB C,
pubmed-meshheading:9846527-Mice, Inbred C3H,
pubmed-meshheading:9846527-Sirolimus
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pubmed:year |
1998
|
pubmed:articleTitle |
Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment.
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pubmed:affiliation |
Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|