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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-12-4
|
| pubmed:abstractText |
The alpha-subunit of human chorionic gonadotropin (hCG-alpha) has previously been found to be expressed in hyperplasias and tumours of numerous endocrine tissues including all those involved in MEN-I syndrome except the parathyroid glands. In the present immunohistochemical investigation of 86 patients with various states of hyperparathyroidism, expression of hCG-alpha by subsets of parathyroid cells was shown in 46 cases (54 per cent) including all states of hyperparathyroidism investigated: primary adenoma (n = 34, 44 per cent); uraemic secondary hyperplasia (n = 34, 53 per cent); MEN-I (n = 13, 77 per cent); MEN-II (n = 2, 100 per cent); and parathyroid carcinoma (n = 3, 100 per cent). Although the number of parathyroid cells expressing hCG-alpha was in general low, the occurrence of numerous immunoreactive cells appeared to be concentrated in primary adenoma and MEN-I (20 and 33 per cent of positive cases, respectively). No expression was found in ten normal control glands, except for very rare cells in one case. Expression of hCG-alpha was in part associated with that of hCG-beta, which appeared to be more commonly expressed than hCG-alpha in cases of secondary hyperparathyroidism. In separate experiments, Bouin fixation was found to preserve the immunoreactivity of hCG-alpha and hCG-beta better than the formalin fixation used in this study, suggesting that the figures may be underestimates. These immunohistochemical results are in agreement with a previous biochemical study showing hCG-alpha and hCG-beta in extracts of parathyroid tumours and extend to the parathyroid glands the otherwise ubiquitous finding of hCG-alpha expression in MEN-I-related neoplasms.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-3417
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
185
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
389-93
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9828837-Adenoma,
pubmed-meshheading:9828837-Adolescent,
pubmed-meshheading:9828837-Adult,
pubmed-meshheading:9828837-Aged,
pubmed-meshheading:9828837-Aged, 80 and over,
pubmed-meshheading:9828837-Chorionic Gonadotropin, beta Subunit, Human,
pubmed-meshheading:9828837-Female,
pubmed-meshheading:9828837-Glycoprotein Hormones, alpha Subunit,
pubmed-meshheading:9828837-Humans,
pubmed-meshheading:9828837-Hyperparathyroidism,
pubmed-meshheading:9828837-Hyperparathyroidism, Secondary,
pubmed-meshheading:9828837-Immunoenzyme Techniques,
pubmed-meshheading:9828837-Male,
pubmed-meshheading:9828837-Middle Aged,
pubmed-meshheading:9828837-Multiple Endocrine Neoplasia,
pubmed-meshheading:9828837-Neoplasm Proteins,
pubmed-meshheading:9828837-Parathyroid Glands,
pubmed-meshheading:9828837-Parathyroid Neoplasms,
pubmed-meshheading:9828837-Retrospective Studies,
pubmed-meshheading:9828837-Uremia
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Expression of the alpha- and beta-subunits of human chorionic gonadotropin by subsets of parathyroid cells in states of hyperparathyroidism.
|
| pubmed:affiliation |
Department of Anatomic Pathology, University of Parma, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|