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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1998-11-18
|
| pubmed:abstractText |
Previous studies have suggested that transepidermal water movement may play an important role in epidermal homeostasis and barrier repair. Here we analyzed cutaneous barrier function, epidermal morphology, and lipid content of the stratum corneum in hairless mice maintained in a high relative humidity (RH > 80%) versus low humidity (RH < 10%) environment for 2 wk. Basal transepidermal water loss was reduced by 31% in animals maintained in a dry versus humid environment. Moreover, the number of lamellar bodies in stratum granulosum cells, the extent of lamellar body exocytosis, and the number of layers of stratum corneum increased in animals kept in a dry environment. Furthermore, the dry weight of the stratum corneum and the thickness of the epidermis also increased in a dry environment. In addition, total stratum corneum lipids increased but lipid analysis revealed no significant differences in lipid distribution. Lastly, barrier recovery following either acetone treatment or tape stripping was accelerated after prolonged prior exposure to a dry environment, while conversely, it was delayed by prior exposure to a humid environment. These studies demonstrate that environmental conditions markedly influence epidermal structure and function, and suggest mechanisms by which the environment could induce or exacerbate various cutaneous disorders.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-202X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
111
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
858-63
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:9804350-Animals,
pubmed-meshheading:9804350-Cell Membrane Permeability,
pubmed-meshheading:9804350-Environment,
pubmed-meshheading:9804350-Extracellular Space,
pubmed-meshheading:9804350-Humidity,
pubmed-meshheading:9804350-Male,
pubmed-meshheading:9804350-Membranes,
pubmed-meshheading:9804350-Mice,
pubmed-meshheading:9804350-Mice, Hairless,
pubmed-meshheading:9804350-Skin
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Exposure to a dry environment enhances epidermal permeability barrier function.
|
| pubmed:affiliation |
Shiseido Research Center, Yokohama, Japan.
|
| pubmed:publicationType |
Journal Article
|