Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1998-11-23
pubmed:abstractText
Vaccine adjuvants exert critical and unique influences on the quality of immune responses induced during active immunizations. We investigated the mechanisms of action of immunological adjuvants in terms of their requirements for cytokine-mediated pathways for adjuvanticity. Antibody responses potentiated by several adjuvants to a Plasmodium falciparum MSP1-19 (C-terminal 19-kDa processing fragment of MSP1) vaccine were studied in gamma interferon (IFN-gamma) or interleukin (IL-4) knockout mice. The levels of anti-MSP1-19 antibodies and the induction of Th1- and Th2-type antibodies were analyzed. Results revealed a spectrum of requirements for cytokine-mediated pathways in the potentiation of immunogenicity, and such requirements were influenced by interactions among individual components of the adjuvant formulations. One adjuvant strictly depended on IFN-gamma to induce appreciable levels of anti-MSP1-19 antibodies, while some formulations required IFN-gamma only for the induction of Th1-type antibodies. Other formulations induced exclusively Th2-type antibodies and were not affected by IFN-gamma knockout. There were three patterns of requirements for IL-4 by various adjuvants in the induction of Th2-type anti-MSP1-19 antibodies. Moreover, the induction of Th1-type anti-MSP1-19 antibodies by adjuvants showed two distinct patterns of regulation by IL-4. The utilization of an IL-4 regulated pathway(s) for the induction of Th2-type antibodies by the same adjuvant differed between mouse strains, suggesting that animal species variability in responses to vaccine adjuvants may be due, at least in part, to differences in the utilization of immune system pathways by an adjuvant among animal hosts.
pubmed:grant
pubmed:commentsCorrections
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pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5329-36
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:9784540-Adjuvants, Immunologic, pubmed-meshheading:9784540-Animals, pubmed-meshheading:9784540-Antibodies, Protozoan, pubmed-meshheading:9784540-Immunoglobulin Isotypes, pubmed-meshheading:9784540-Interferon-gamma, pubmed-meshheading:9784540-Interleukin-4, pubmed-meshheading:9784540-Liposomes, pubmed-meshheading:9784540-Malaria, pubmed-meshheading:9784540-Merozoite Surface Protein 1, pubmed-meshheading:9784540-Mice, pubmed-meshheading:9784540-Mice, Inbred BALB C, pubmed-meshheading:9784540-Mice, Inbred C57BL, pubmed-meshheading:9784540-Mice, Knockout, pubmed-meshheading:9784540-Peptide Fragments, pubmed-meshheading:9784540-Plasmodium falciparum, pubmed-meshheading:9784540-Recombinant Proteins, pubmed-meshheading:9784540-Species Specificity, pubmed-meshheading:9784540-Vaccination
pubmed:year
1998
pubmed:articleTitle
Pathways for potentiation of immunogenicity during adjuvant-assisted immunizations with Plasmodium falciparum major merozoite surface protein 1.
pubmed:affiliation
Department of Tropical Medicine, University of Hawaii, Honolulu, Hawaii 96816, USA. ghui@hawaii.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.