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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-10-30
|
| pubmed:abstractText |
We studied a 29-year-old woman with myopathy since childhood with evidence of mitochondrial DNA (mtDNA) depletion. Muscle biopsy sample showed cytochrome c oxidase (COX)-negative fibers. Biochemistry showed COX deficiency. Southern blot analysis showed 76% depletion of mtDNA as compared with controls. This patient's clinical course suggests that long survival is possible in some patients with mtDNA depletion.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0028-3878
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1190-3
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9781557-Adult,
pubmed-meshheading:9781557-Biopsy,
pubmed-meshheading:9781557-Blotting, Southern,
pubmed-meshheading:9781557-Cytochrome-c Oxidase Deficiency,
pubmed-meshheading:9781557-DNA, Mitochondrial,
pubmed-meshheading:9781557-Female,
pubmed-meshheading:9781557-Humans,
pubmed-meshheading:9781557-Mitochondrial Myopathies,
pubmed-meshheading:9781557-Muscle, Skeletal,
pubmed-meshheading:9781557-Succinate Dehydrogenase,
pubmed-meshheading:9781557-Survivors
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Mitochondrial DNA depletion in a patient with long survival.
|
| pubmed:affiliation |
H. Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Diseases, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Case Reports
|