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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0007586,
umls-concept:C0019682,
umls-concept:C0021311,
umls-concept:C0032105,
umls-concept:C0035668,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0441889,
umls-concept:C1332714,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1706438,
umls-concept:C1879547,
umls-concept:C2698600
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pubmed:issue |
5
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pubmed:dateCreated |
1998-12-10
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pubmed:abstractText |
The relationship between T cell activation and human immunodeficiency virus type 1 (HIV-1) replication was studied in HIV-infected subjects, 20 with and 10 without anti-HIV treatment. Expression of Ki-67 proliferation-associated antigen was increased in CD4+ and CD8+ T cells and correlated with HLA-DR. In subjects without anti-HIV treatment, the plasma HIV-1 RNA level correlated with HLA-DR in CD4+ T cells, with Ki-67 in CD8+ T cells, and with expression of CD38 in both T cell subsets. A proportion of treated subjects had increased T cell activation despite 4 months of highly active antiretroviral treatment (HAART). In subjects receiving HAART, a high percentage of HLA-DR+ CD4+ T cells was associated with signs of opportunistic infections. This work supports the concept that, in the natural course of HIV-1 infection, HIV replication itself leads to general T cell activation and that opportunistic infections generate additional CD4+ T cell activation and HIV replication.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP-ribosyl Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/CD38 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Ki-67 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NAD Nucleosidase,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/beta 2-Microglobulin
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1899
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
178
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1279-87
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9780247-ADP-ribosyl Cyclase,
pubmed-meshheading:9780247-Adult,
pubmed-meshheading:9780247-Antigens, CD,
pubmed-meshheading:9780247-Antigens, CD38,
pubmed-meshheading:9780247-Antigens, Differentiation,
pubmed-meshheading:9780247-Biological Markers,
pubmed-meshheading:9780247-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9780247-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9780247-HIV Antigens,
pubmed-meshheading:9780247-HIV Infections,
pubmed-meshheading:9780247-HIV-1,
pubmed-meshheading:9780247-Humans,
pubmed-meshheading:9780247-Ki-67 Antigen,
pubmed-meshheading:9780247-Lymphocyte Activation,
pubmed-meshheading:9780247-Membrane Glycoproteins,
pubmed-meshheading:9780247-Middle Aged,
pubmed-meshheading:9780247-NAD+ Nucleosidase,
pubmed-meshheading:9780247-RNA, Viral,
pubmed-meshheading:9780247-Virus Replication,
pubmed-meshheading:9780247-beta 2-Microglobulin
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pubmed:year |
1998
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pubmed:articleTitle |
Activation and cell cycle antigens in CD4+ and CD8+ T cells correlate with plasma human immunodeficiency virus (HIV-1) RNA level in HIV-1 infection.
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pubmed:affiliation |
Department of Medical Microbiology, Leiden University Medical Center, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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