Linked Life Data

9779226

Source:http://linkedlifedata.com/resource/pubmed/id/9779226

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-1-14
pubmed:abstractText
Prediction of outcome after shunt-therapy in chronic hydrocephalus syndrome is uncertain. Pathology reveals an impairment of cerebral blood flow (CBF). Based on this, we evaluated CBF and its significance for the assessment of prognosis. In 21 patients (mean age 69 years) selected for surgery, CBF was measured by PET (15O-H2O) before, about one week and 7 months (n = 14) after shunting. CBF was computed by a 1-compartmental model in the territories of the ACA, MCA and PCA. One PET slice in the height of the maximum projection of both cellae mediae was chosen. CBF data were standardized by cluster analysis. Three CBFClusters with significantly different CBF levels prior to shunting in the ACA, MCA and PCA territory, respectively, referred to the sample average (38.2 ml/100 ml/min) were found. These CBFClusters differed in clinical outcome: almost 50% and 90% of patients improved clinically in CBFCluster I, with a perfusion level lower than average, after one week and 7 months, respectively. In contrast, patients of CBFCluster II with an average perfusion did not improve. CBF changes 7 months after shunting related to global CBF before surgery showed a relationship with the clinical course. Clinical outcome corresponded with preoperative global CBF values. Cerebral blood flow lower than average forecasts clinical improvement. Our results suggest that measurement of CBF adds to the indication for surgery.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0065-1419
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
347-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Cerebral blood flow in chronic hydrocephalus--a parameter indicating shunt failure--new aspects.
pubmed:affiliation
Neurochirurgische Klinik, Medizinische Hochschule Hannover, Federal Republic of Germany.
pubmed:publicationType
Journal Article