| pubmed-article:9774672 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9774672 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9774672 | lifeskim:mentions | umls-concept:C0076918 | lld:lifeskim |
| pubmed-article:9774672 | lifeskim:mentions | umls-concept:C0076919 | lld:lifeskim |
| pubmed-article:9774672 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:9774672 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:9774672 | lifeskim:mentions | umls-concept:C0178555 | lld:lifeskim |
| pubmed-article:9774672 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:9774672 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:9774672 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:9774672 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:9774672 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:9774672 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:9774672 | pubmed:dateCreated | 1998-11-23 | lld:pubmed |
| pubmed-article:9774672 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:abstractText | TATA-binding protein-associated factors (TAFIIs) within TFIID control differential gene transcription through interactions with both activators and core promoter elements. In particular, TAFII150 contributes to initiator-dependent transcription through an unknown mechanism. Here, we address whether TAFIIs within TFIID are sufficient, in conjunction with highly purified general transcription factors (GTFs), for differential core promoter-dependent transcription by RNA polymerase II and whether additional cofactors are required. We identify the human homologue of Drosophila TAFII150 through cognate cDNA cloning and show that it is a tightly associated component of human TFIID. More importantly, we demonstrate that the human TAFII150-containing TFIID complex is not sufficient, in the context of all purified GTFs and RNA polymerase II, to mediate transcription synergism between TATA and initiator elements and initiator-directed transcription from a TAFII-dependent TATA-less promoter. Therefore, TAFII-promoter interactions are not sufficient for the productive core promoter-selective functions of TFIID. Consistent with this finding, we have partially purified novel cofactor activities (TICs) that potentiate the TAFII-mediated synergism between TATA and initiator elements (TIC-1) and TAFII-dependent transcription from TATA-less promoters (TIC-2 and -3). Furthermore, we demonstrate an essential function for TFIIA in TIC- and TAFII-dependent basal transcription from a TATA-less promoter. Our results reveal a parallel between the basal transcription activity of TAFIIs through core promoter elements and TAFII-dependent activator function. | lld:pubmed |
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| pubmed-article:9774672 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9774672 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9774672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9774672 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9774672 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:9774672 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:9774672 | pubmed:author | pubmed-author:NEWM IMI | lld:pubmed |
| pubmed-article:9774672 | pubmed:author | pubmed-author:MartinezEE | lld:pubmed |
| pubmed-article:9774672 | pubmed:author | pubmed-author:RoederR GRG | lld:pubmed |
| pubmed-article:9774672 | pubmed:author | pubmed-author:TayWW | lld:pubmed |
| pubmed-article:9774672 | pubmed:author | pubmed-author:YuanC XCX | lld:pubmed |
| pubmed-article:9774672 | pubmed:author | pubmed-author:PalhanVV | lld:pubmed |
| pubmed-article:9774672 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9774672 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:9774672 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9774672 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9774672 | pubmed:pagination | 6571-83 | lld:pubmed |
