Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5388
pubmed:dateCreated
1998-10-30
pubmed:abstractText
Toxic epidermal necrolysis (TEN, Lyell's syndrome) is a severe adverse drug reaction in which keratinocytes die and large sections of epidermis separate from the dermis. Keratinocytes normally express the death receptor Fas (CD95); those from TEN patients were found to express lytically active Fas ligand (FasL). Antibodies present in pooled human intravenous immunoglobulins (IVIG) blocked Fas-mediated keratinocyte death in vitro. In a pilot study, 10 consecutive individuals with clinically and histologically confirmed TEN were treated with IVIG; disease progression was rapidly reversed and the outcome was favorable in all cases. Thus, Fas-FasL interactions are directly involved in the epidermal necrolysis of TEN, and IVIG may be an effective treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
282
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
490-3
pubmed:dateRevised
2007-3-19
pubmed:meshHeading
pubmed-meshheading:9774279-Adolescent, pubmed-meshheading:9774279-Adult, pubmed-meshheading:9774279-Aged, pubmed-meshheading:9774279-Aged, 80 and over, pubmed-meshheading:9774279-Antibodies, Blocking, pubmed-meshheading:9774279-Antigens, CD95, pubmed-meshheading:9774279-Apoptosis, pubmed-meshheading:9774279-Child, pubmed-meshheading:9774279-Dermis, pubmed-meshheading:9774279-Disease Progression, pubmed-meshheading:9774279-Epidermal Necrolysis, Toxic, pubmed-meshheading:9774279-Epidermis, pubmed-meshheading:9774279-Fas Ligand Protein, pubmed-meshheading:9774279-Female, pubmed-meshheading:9774279-Humans, pubmed-meshheading:9774279-Immunoglobulins, Intravenous, pubmed-meshheading:9774279-Jurkat Cells, pubmed-meshheading:9774279-Keratinocytes, pubmed-meshheading:9774279-Male, pubmed-meshheading:9774279-Membrane Glycoproteins, pubmed-meshheading:9774279-Middle Aged, pubmed-meshheading:9774279-Pilot Projects
pubmed:year
1998
pubmed:articleTitle
Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
pubmed:affiliation
Department of Dermatology, Geneva University Medical School, CH-1211 Geneva 4, Switzerland.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't