rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5388
|
pubmed:dateCreated |
1998-10-30
|
pubmed:abstractText |
Toxic epidermal necrolysis (TEN, Lyell's syndrome) is a severe adverse drug reaction in which keratinocytes die and large sections of epidermis separate from the dermis. Keratinocytes normally express the death receptor Fas (CD95); those from TEN patients were found to express lytically active Fas ligand (FasL). Antibodies present in pooled human intravenous immunoglobulins (IVIG) blocked Fas-mediated keratinocyte death in vitro. In a pilot study, 10 consecutive individuals with clinically and histologically confirmed TEN were treated with IVIG; disease progression was rapidly reversed and the outcome was favorable in all cases. Thus, Fas-FasL interactions are directly involved in the epidermal necrolysis of TEN, and IVIG may be an effective treatment.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0036-8075
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
16
|
pubmed:volume |
282
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
490-3
|
pubmed:dateRevised |
2007-3-19
|
pubmed:meshHeading |
pubmed-meshheading:9774279-Adolescent,
pubmed-meshheading:9774279-Adult,
pubmed-meshheading:9774279-Aged,
pubmed-meshheading:9774279-Aged, 80 and over,
pubmed-meshheading:9774279-Antibodies, Blocking,
pubmed-meshheading:9774279-Antigens, CD95,
pubmed-meshheading:9774279-Apoptosis,
pubmed-meshheading:9774279-Child,
pubmed-meshheading:9774279-Dermis,
pubmed-meshheading:9774279-Disease Progression,
pubmed-meshheading:9774279-Epidermal Necrolysis, Toxic,
pubmed-meshheading:9774279-Epidermis,
pubmed-meshheading:9774279-Fas Ligand Protein,
pubmed-meshheading:9774279-Female,
pubmed-meshheading:9774279-Humans,
pubmed-meshheading:9774279-Immunoglobulins, Intravenous,
pubmed-meshheading:9774279-Jurkat Cells,
pubmed-meshheading:9774279-Keratinocytes,
pubmed-meshheading:9774279-Male,
pubmed-meshheading:9774279-Membrane Glycoproteins,
pubmed-meshheading:9774279-Middle Aged,
pubmed-meshheading:9774279-Pilot Projects
|
pubmed:year |
1998
|
pubmed:articleTitle |
Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin.
|
pubmed:affiliation |
Department of Dermatology, Geneva University Medical School, CH-1211 Geneva 4, Switzerland.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
|