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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1998-11-13
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pubmed:abstractText |
FGF-1 stimulated DNA synthesis and induced expression of IL-2 receptors in the murine fibrosarcoma cell line, F69-3. Concomitant treatment with IL-2 abolished the stimulation of DNA synthesis, but not binding of FGF-1 to the FGF-receptors or subsequent endocytosis of the bound growth factor. Also, it did not inhibit activation of the FGF-receptor tyrosine kinase or stimulation of the downstream effector, MAP kinase. Treatment with IL-2 prevented transport of FGF-1 to the nuclear fraction in a time- and dose-dependent manner that parallelled the inhibition of FGF-1 stimulated DNA synthesis. The data support our earlier finding that transport of FGF-1 to the nucleus is an important event in the mechanism of stimulation of DNA synthesis induced by the growth factor, and they demonstrate that treatment with a cytokine can modulate the cellular response to FGF-1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-4827
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1998 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
244
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-70
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9770349-Animals,
pubmed-meshheading:9770349-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:9770349-Cell Nucleus,
pubmed-meshheading:9770349-DNA, Neoplasm,
pubmed-meshheading:9770349-Enzyme Activation,
pubmed-meshheading:9770349-Fibroblast Growth Factor 1,
pubmed-meshheading:9770349-Fibroblast Growth Factor 2,
pubmed-meshheading:9770349-Fibrosarcoma,
pubmed-meshheading:9770349-Humans,
pubmed-meshheading:9770349-Interleukin-2,
pubmed-meshheading:9770349-Mice,
pubmed-meshheading:9770349-Mice, Inbred BALB C,
pubmed-meshheading:9770349-Mice, Nude,
pubmed-meshheading:9770349-Protein Binding,
pubmed-meshheading:9770349-Receptors, Fibroblast Growth Factor,
pubmed-meshheading:9770349-Signal Transduction,
pubmed-meshheading:9770349-Tumor Cells, Cultured
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pubmed:year |
1998
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pubmed:articleTitle |
Modulation by interleukin-2 of cellular response to fibroblast growth factor-1 in F69-3 fibrosarcoma cells.
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pubmed:affiliation |
Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, 0310 Oslo, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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