Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-10-23
pubmed:abstractText
Apoptosis is a type of cell death that occurs during morphogenesis and development of the immune system. One of the mechanisms is mediated through the Fas and Fas ligand (FasL) pathway. To determine the possible involvement of Fas and its ligand in salivary gland destruction, we analysed the appearance of nuclei with DNA fragmentation by using nick end labelling (TUNEL) and the expression of Fas and FasL by immunohistochemistry in labial salivary glands. Furthermore, we compared the features of apoptosis in labial salivary glands between HTLV-I- and HTLV-I+ SS. When the frozen sections of 10 primary SS patients in the absence of anti-HTLV-I antibody were examined, several apoptotic cells were found in the acinar and ductal epithelial cells as well as infiltrated mononuclear cells. Both Fas and FasL were detected in the infiltrated mononuclear cells. Acinar epithelial cells, which are surrounded by FasL+ mononuclear cells, were also double-positive with Fas and FasL, although the expression of FasL was localized at their apical border, suggesting that apoptosis of mononuclear cells was achieved by activation-induced mechanisms through Fas/FasL pathways, and that of acinar epithelial cells was mediated by FasL derived from either acinar epithelial cells themselves or infiltrated mononuclear cells. Interestingly, Fas expression in ductal epithelial cells was localized around the lumen side of the ducts, indicating that FasL secreted from acinar epithelial cells may induce Fas-mediated apoptosis of ductal epithelial cells. We also studied the labial salivary glands from nine SS patients with anti-HTLV-I antibodies. There was no significant difference in the occurrence of apoptotic cells or in the expression of Fas and FasL between HTLV-I+ and HTLV-I- SS patients. It was of note that neither the expression of Fas and FasL nor the presence of apoptotic cells were determined in labial salivary glands from subjects without SS. These findings indicate that Fas-mediated apoptosis in salivary glands could be involved in the pathological manifestations of SS, irrespective of HTLV-I seropositivity.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-1326761, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-1352097, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-1400587, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-1713127, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-2788824, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-2881513, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-6600176, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-7509364, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-7530336, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-7530337, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-7532682, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-7706720, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-8137431, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-8452579, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-8485911, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-8612534, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-8663110, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-8702433, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-8976873, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-9008604, http://linkedlifedata.com/resource/pubmed/commentcorrection/9764611-9135218
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
106-12
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Apoptosis in labial salivary glands from Sjögren's syndrome (SS) patients: comparison with human T lymphotropic virus-I (HTLV-I)-seronegative and -seropositive SS patients.
pubmed:affiliation
First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki City, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't