Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1998-10-23
|
| pubmed:abstractText |
In Bacteria and Eukarya, ssDNA-binding proteins are central to most aspects of DNA metabolism. Until recently, however, no counterpart of an ssDNA-binding protein had been identified in the third domain of life, Archaea. Here, we report the discovery of a novel type of ssDNA-binding protein in the genomes of several archaeons. These proteins, in contrast to all known members of this protein family, possess four conserved DNA-binding sites within a single polypeptide or, in one case, two polypeptides. This peculiar structural organization allows us to propose a model for the evolution of this class of proteins.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0968-0004
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
23
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
273-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9757822-Amino Acid Sequence,
pubmed-meshheading:9757822-Archaeal Proteins,
pubmed-meshheading:9757822-Binding Sites,
pubmed-meshheading:9757822-Conserved Sequence,
pubmed-meshheading:9757822-DNA, Single-Stranded,
pubmed-meshheading:9757822-DNA-Binding Proteins,
pubmed-meshheading:9757822-Evolution, Molecular,
pubmed-meshheading:9757822-Methanococcus,
pubmed-meshheading:9757822-Models, Biological,
pubmed-meshheading:9757822-Molecular Sequence Data,
pubmed-meshheading:9757822-Replication Protein A,
pubmed-meshheading:9757822-Sequence Alignment,
pubmed-meshheading:9757822-Sequence Homology, Amino Acid
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Novel homologs of replication protein A in archaea: implications for the evolution of ssDNA-binding proteins.
|
| pubmed:affiliation |
Section of Microbiology, University of California, Davis 95616-8665, USA.
|
| pubmed:publicationType |
Journal Article
|