| pubmed-article:9748297 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9748297 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:9748297 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:9748297 | lifeskim:mentions | umls-concept:C0026845 | lld:lifeskim |
| pubmed-article:9748297 | lifeskim:mentions | umls-concept:C0015677 | lld:lifeskim |
| pubmed-article:9748297 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:9748297 | lifeskim:mentions | umls-concept:C0178666 | lld:lifeskim |
| pubmed-article:9748297 | lifeskim:mentions | umls-concept:C0278372 | lld:lifeskim |
| pubmed-article:9748297 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:9748297 | pubmed:issue | 40 | lld:pubmed |
| pubmed-article:9748297 | pubmed:dateCreated | 1998-11-12 | lld:pubmed |
| pubmed-article:9748297 | pubmed:abstractText | A high fat diet causes resistance of skeletal muscle glucose transport to insulin and contractions. We tested the hypothesis that fat feeding causes a change in plasma membrane composition that interferes with functioning of glucose transporters and/or insulin receptors. Epitrochlearis muscles of rats fed a high (50% of calories) fat diet for 8 weeks showed approximately 50% decreases in insulin- and contraction-stimulated 3-O-methylglucose transport. Similar decreases in stimulated glucose transport activity occurred in muscles of wild-type mice with 4 weeks of fat feeding. In contrast, GLUT1 overexpressing muscles of transgenic mice fed a high fat diet showed no decreases in their high rates of glucose transport, providing evidence against impaired glucose transporter function. Insulin-stimulated system A amino acid transport, insulin receptor (IR) tyrosine kinase activity, and insulin-stimulated IR and IRS-1 tyrosine phosphorylation were all normal in muscles of rats fed the high fat diet for 8 weeks. However, after 30 weeks on the high fat diet, there was a significant reduction in insulin-stimulated tyrosine phosphorylation in muscle. The increases in GLUT4 at the cell surface induced by insulin or muscle contractions, measured with the 3H-labeled 2-N-4-(1-azi-2,2, 2-trifluoroethyl)-benzoyl-1,3-bis-(D-mannose-4-yloxy)-2-propyla min e photolabel, were 26-36% smaller in muscles of the 8-week high fat-fed rats as compared with control rats. Our findings provide evidence that (a) impairment of muscle glucose transport by 8 weeks of high fat feeding is not due to plasma membrane composition-related reductions in glucose transporter or insulin receptor function, (b) a defect in insulin receptor signaling is a late event, not a primary cause, of the muscle insulin resistance induced by fat feeding, and (c) impaired GLUT4 translocation to the cell surface plays a major role in the decrease in stimulated glucose transport. | lld:pubmed |
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| pubmed-article:9748297 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:9748297 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9748297 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9748297 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9748297 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:9748297 | pubmed:author | pubmed-author:HansenP APA | lld:pubmed |
| pubmed-article:9748297 | pubmed:author | pubmed-author:HolloszyJ OJO | lld:pubmed |
| pubmed-article:9748297 | pubmed:author | pubmed-author:ChenM MMM | lld:pubmed |
| pubmed-article:9748297 | pubmed:author | pubmed-author:MuecklerMM | lld:pubmed |
| pubmed-article:9748297 | pubmed:author | pubmed-author:KIMS CSC | lld:pubmed |
| pubmed-article:9748297 | pubmed:author | pubmed-author:MarshallB ABA | lld:pubmed |
| pubmed-article:9748297 | pubmed:author | pubmed-author:NolteL ALA | lld:pubmed |
| pubmed-article:9748297 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9748297 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:9748297 | pubmed:volume | 273 | lld:pubmed |
| pubmed-article:9748297 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9748297 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9748297 | pubmed:pagination | 26157-63 | lld:pubmed |
| pubmed-article:9748297 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:9748297 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9748297 | pubmed:articleTitle | A high fat diet impairs stimulation of glucose transport in muscle. Functional evaluation of potential mechanisms. | lld:pubmed |
| pubmed-article:9748297 | pubmed:affiliation | Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA. phansen@imgate.wustl.edu | lld:pubmed |
| pubmed-article:9748297 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9748297 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9748297 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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