|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1998-10-1
|
|
pubmed:abstractText |
N-methyl-D-aspartate (NDMA) antagonists have minimal effects on acute nociception but block facilitated states of processing. In contrast, the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonists decrease acute noxious responses. Morphine (a mu-opioid agonist) can also decrease acute nociceptive processing. The authors hypothesized that the interaction between morphine and AMPA receptor antagonists would be synergistic, whereas morphine and NMDA antagonists show no such interaction in acute nociception.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0003-3022
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
89
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
715-22
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:9743410-Analgesia,
pubmed-meshheading:9743410-Analgesics, Opioid,
pubmed-meshheading:9743410-Animals,
pubmed-meshheading:9743410-Dose-Response Relationship, Drug,
pubmed-meshheading:9743410-Drug Interactions,
pubmed-meshheading:9743410-Excitatory Amino Acid Antagonists,
pubmed-meshheading:9743410-Hot Temperature,
pubmed-meshheading:9743410-Morphine,
pubmed-meshheading:9743410-N-Methylaspartate,
pubmed-meshheading:9743410-Pain,
pubmed-meshheading:9743410-Rats,
pubmed-meshheading:9743410-Rats, Sprague-Dawley,
pubmed-meshheading:9743410-Receptors, Opioid, mu,
pubmed-meshheading:9743410-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Effects of intrathecal NMDA and non-NMDA antagonists on acute thermal nociception and their interaction with morphine.
|
|
pubmed:affiliation |
Department of Anesthesiology, University of California, San Diego, La Jolla, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
