| pubmed-article:9742943 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C0109317 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C1705767 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C1882687 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C0380051 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C1370600 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C1366882 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C1150579 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C1333340 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C1705791 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:9742943 | lifeskim:mentions | umls-concept:C1549542 | lld:lifeskim |
| pubmed-article:9742943 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9742943 | pubmed:dateCreated | 1998-10-8 | lld:pubmed |
| pubmed-article:9742943 | pubmed:abstractText | Adenosine and mitogen-activated protein kinases (MAPKs) have been separately implicated in cardiac ischaemic preconditioning. We investigated the activation of MAPK subfamilies by adenosine in perfused rat hearts. p38-MAPK was rapidly phosphorylated and activated (10-fold activation, maximal at 5 min) by 10 mM adenosine, as was the p38-MAPK substrate, MAPKAPK2 (4.5-fold). SAPKs/JNKs were activated (5-fold) and ERKs were phosphorylated (both maximal at 5 min). The concentration dependences of activation of p38-MAPK and ERKs were biphasic with a 'high affinity' component (maximal at 10-100 microM adenosine) and a 'low affinity' component that had not saturated at 10 mM. SAPKs/JNKs were activated only by 10 mM adenosine. These results are consistent with MAPK involvement in adenosine-mediated ischaemic preconditioning. | lld:pubmed |
| pubmed-article:9742943 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9742943 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9742943 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9742943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9742943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9742943 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9742943 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:9742943 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:9742943 | pubmed:author | pubmed-author:SugdenP HPH | lld:pubmed |
| pubmed-article:9742943 | pubmed:author | pubmed-author:LowF NFN | lld:pubmed |
| pubmed-article:9742943 | pubmed:author | pubmed-author:ClerkAA | lld:pubmed |
| pubmed-article:9742943 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9742943 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:9742943 | pubmed:volume | 434 | lld:pubmed |
| pubmed-article:9742943 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9742943 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9742943 | pubmed:pagination | 305-8 | lld:pubmed |
| pubmed-article:9742943 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:9742943 | pubmed:meshHeading | pubmed-meshheading:9742943-... | lld:pubmed |
| pubmed-article:9742943 | pubmed:meshHeading | pubmed-meshheading:9742943-... | lld:pubmed |
| pubmed-article:9742943 | pubmed:meshHeading | pubmed-meshheading:9742943-... | lld:pubmed |
| pubmed-article:9742943 | pubmed:meshHeading | pubmed-meshheading:9742943-... | lld:pubmed |
| pubmed-article:9742943 | pubmed:meshHeading | pubmed-meshheading:9742943-... | lld:pubmed |
| pubmed-article:9742943 | pubmed:meshHeading | pubmed-meshheading:9742943-... | lld:pubmed |
| pubmed-article:9742943 | pubmed:meshHeading | pubmed-meshheading:9742943-... | lld:pubmed |
| pubmed-article:9742943 | pubmed:meshHeading | pubmed-meshheading:9742943-... | lld:pubmed |
| pubmed-article:9742943 | pubmed:meshHeading | pubmed-meshheading:9742943-... | lld:pubmed |
| pubmed-article:9742943 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9742943 | pubmed:articleTitle | Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart. | lld:pubmed |
| pubmed-article:9742943 | pubmed:affiliation | NHLI Division (Cardiac Medicine), Imperial College School of Medicine, London, UK. | lld:pubmed |
| pubmed-article:9742943 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9742943 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9742943 | lld:pubmed |
