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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
1998-9-28
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pubmed:abstractText |
Brain serotonin (5-HT) has been implicated in a number of physiological processes and pathological conditions. These effects are mediated by at least 14 different 5-HT receptors. We have inactivated the gene encoding the 5-HT1A receptor in mice and found that receptor-deficient animals have an increased tendency to avoid a novel and fearful environment and to escape a stressful situation, behaviors consistent with an increased anxiety and stress response. Based on the role of the 5-HT1A receptor in the feedback regulation of the 5-HT system, we hypothesize that an increased serotonergic neurotransmission is responsible for the anxiety-like behavior of receptor-deficient animals. This view is consistent with earlier studies showing that pharmacological activation of the 5-HT system is anxiogenic in animal models and also in humans.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-1410142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-1886080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-2031574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-2078272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-2078279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-2078280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-2078282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-2080190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-2093165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-2442002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-2850622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-2901680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-3124184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-3579504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-596982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-6130954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-7566118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-7630926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-7644567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-7686633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-7691626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-7700534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-7772647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-7853210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-7932797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-7984266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8014870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8055253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8170624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8182429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8209254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8333959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8336817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8364729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8419553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8506303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8532615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8539333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8540894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8626793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8723200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8724978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8768728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8788530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8829630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8849726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-8931271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-9116165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-9119362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-9142756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9724773-9237538
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10734-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9724773-Animals,
pubmed-meshheading:9724773-Anxiety,
pubmed-meshheading:9724773-Base Sequence,
pubmed-meshheading:9724773-Behavior, Animal,
pubmed-meshheading:9724773-Brain,
pubmed-meshheading:9724773-DNA Primers,
pubmed-meshheading:9724773-Female,
pubmed-meshheading:9724773-Genotype,
pubmed-meshheading:9724773-Male,
pubmed-meshheading:9724773-Mice,
pubmed-meshheading:9724773-Mice, Inbred BALB C,
pubmed-meshheading:9724773-Mice, Knockout,
pubmed-meshheading:9724773-Receptors, Serotonin,
pubmed-meshheading:9724773-Receptors, Serotonin, 5-HT1
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pubmed:year |
1998
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pubmed:articleTitle |
Increased anxiety of mice lacking the serotonin1A receptor.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544-1014, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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