Linked Life Data

9714896

Source:http://linkedlifedata.com/resource/pubmed/id/9714896

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-10-29
pubmed:abstractText
Transcriptional regulation by steroid/nuclear receptors is the central theme of hormone action that controls key aspects of cell differentiation, development, and homeostasis. The molecular mechanisms of gene activation and repression by the receptors have been investigated extensively in recent years. Particularly, several new proteins involved in this signaling pathway have been identified, cloned, and demonstrated to modulate transcription in concert with nuclear receptors. In the absence of hormone, unliganded receptors interact with a family of transcriptional corepressors, including SMRT and N-CoR, which target histone deacetylases to establish a condensed and repressed chromatin structure. Upon hormone binding, the corepressor complex is replaced by a coactivator complex, containing SRC1/TIF2/RAC3 and CBP/p300, which target histone acetyltransferases to generate a transcriptionally accessible chromatin structure. These studies initiate a new era in the history of hormone research and provide novel entry points for understanding the mechanisms of transcriptional regulation by steroid/nuclear receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1045-4403
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-90
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Coactivation and corepression in transcriptional regulation by steroid/nuclear hormone receptors.
pubmed:affiliation
Department of Pharmacology and Molecular Toxicology, University of Massachusetts Medical School, Worcester 01655-0126, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't