Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-10-1
pubmed:databankReference
pubmed:abstractText
Osteoclastogenesis inhibitory factor (OCIF) is a novel soluble-form member of the tumor necrosis factor receptor family and is involved in the regulation of bone mass. Here we isolated genomic and cDNA clones for mouse OCIF and determined their structures. Mouse OCIF gene spans 29 kb and contains five exons of 270, 367, 192, 225 and 1765 bp long. Four cysteine-rich domains and two death domain homologous regions characterized in human OCIF are rigidly conserved in mouse OCIF. The onset of OCIF gene expression in mouse embryogenesis is at day 8.5. In a pregnant female mouse, OCIF gene is expressed in decidua, a maternal tissue surrounding each embryo, immediately after implantation. The isolation of mouse OCIF gene should facilitate studies on OCIF knock-out mice for a better understanding of the role of OCIF in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0378-1119
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
215
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
339-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:9714833-Amino Acid Sequence, pubmed-meshheading:9714833-Animals, pubmed-meshheading:9714833-Base Sequence, pubmed-meshheading:9714833-Cloning, Molecular, pubmed-meshheading:9714833-Conserved Sequence, pubmed-meshheading:9714833-DNA, Complementary, pubmed-meshheading:9714833-Decidua, pubmed-meshheading:9714833-Embryo Implantation, pubmed-meshheading:9714833-Embryonic and Fetal Development, pubmed-meshheading:9714833-Exons, pubmed-meshheading:9714833-Female, pubmed-meshheading:9714833-Gene Expression Regulation, Developmental, pubmed-meshheading:9714833-Glycoproteins, pubmed-meshheading:9714833-Humans, pubmed-meshheading:9714833-Mice, pubmed-meshheading:9714833-Mice, Inbred ICR, pubmed-meshheading:9714833-Molecular Sequence Data, pubmed-meshheading:9714833-Osteoprotegerin, pubmed-meshheading:9714833-Polymerase Chain Reaction, pubmed-meshheading:9714833-Pregnancy, pubmed-meshheading:9714833-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:9714833-Receptors, Tumor Necrosis Factor, pubmed-meshheading:9714833-Recombinant Proteins, pubmed-meshheading:9714833-Restriction Mapping
pubmed:year
1998
pubmed:articleTitle
Structure of the mouse osteoclastogenesis inhibitory factor (OCIF) gene and its expression in embryogenesis.
pubmed:affiliation
Research Institute of Life Science, Snow Brand Milk Products, Co. Ltd., 519, Ishibashi-machi, Shimotsuga-gun, Tochigi, 329-0512, Japan.
pubmed:publicationType
Journal Article