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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1998-8-31
|
| pubmed:abstractText |
Nonspecific protein binding is a commonly encountered problem with synthetic molecules designed as enzyme inhibitors. When the substrate for the enzymatic reaction is itself a protein, such nonspecific protein binding can also occur. Here, we demonstrate that this phenomenon can have a dramatic effect on the steady-state kinetic evaluation of such inhibitors.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0006-2952
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
55
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1785-90
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading |
pubmed-meshheading:9714296-Catalysis,
pubmed-meshheading:9714296-Dose-Response Relationship, Drug,
pubmed-meshheading:9714296-Enzyme Inhibitors,
pubmed-meshheading:9714296-Enzymes,
pubmed-meshheading:9714296-Kinetics,
pubmed-meshheading:9714296-Models, Biological,
pubmed-meshheading:9714296-Protein Binding
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Kinetic effects due to nonspecific substrate-inhibitor interactions in enzymatic reactions.
|
| pubmed:affiliation |
Department of Chemical Enzymology, The DuPont Merck Research Laboratories, Wilmington, DE 19880-0400, USA. Copelara@lldmpc.dnet.dupont.com
|
| pubmed:publicationType |
Journal Article
|