Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1998-8-21
pubmed:abstractText
Müllerian inhibiting substance (MIS), alpha-inhibin, and CD99 are expressed by normal and neoplastic sex cord and stromal gonadal derivatives. The expression of MIS, inhibin, and CD99 was evaluated by immunohistochemistry in a series of 19 sex cord-stromal tumors and seven ovarian endometrioid carcinomas resembling sex cord-stromal tumors. Normal ovaries and testes from patients with the androgen insensitivity syndrome were used as control. All three markers were detected in primordial ovarian follicles and immature seminiferous tubules. Both inhibin and MIS were expressed by all sex cord-stromal tumors, but inhibin immunostaining appeared stronger and more diffusely distributed. CD99 was expressed by all adult and juvenile granulosa cell tumors, but only focally by Sertoli-Leydig cell tumors. In Sertoli-Leydig cell tumors, the three markers were predominantly expressed by the Sertoli cells. None of the seven endometrioid carcinomas with a sex cord-stromal pattern was positive for MIS or inhibin; two of them reacted for CD99, but their staining patterns were not membranous. Inhibin immunoreactivity was also detected in foci of stromal luteinization, occasionally present in these tumors. MIS, inhibin, and CD99 are potentially useful markers in the differential diagnosis between sex cord-stromal tumors and endometrioid carcinomas resembling sex cord-stromal tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0046-8177
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
840-5
pubmed:dateRevised
2010-9-1
pubmed:meshHeading
pubmed-meshheading:9712426-Adult, pubmed-meshheading:9712426-Anti-Mullerian Hormone, pubmed-meshheading:9712426-Antigens, CD, pubmed-meshheading:9712426-Carcinoma, Endometrioid, pubmed-meshheading:9712426-Cell Adhesion Molecules, pubmed-meshheading:9712426-Female, pubmed-meshheading:9712426-Glycoproteins, pubmed-meshheading:9712426-Growth Inhibitors, pubmed-meshheading:9712426-Humans, pubmed-meshheading:9712426-Immunoenzyme Techniques, pubmed-meshheading:9712426-Inhibins, pubmed-meshheading:9712426-Male, pubmed-meshheading:9712426-Mullerian Ducts, pubmed-meshheading:9712426-Ovarian Neoplasms, pubmed-meshheading:9712426-Ovary, pubmed-meshheading:9712426-Peptides, pubmed-meshheading:9712426-Sex Cord-Gonadal Stromal Tumors, pubmed-meshheading:9712426-Testicular Hormones, pubmed-meshheading:9712426-Testis, pubmed-meshheading:9712426-Tumor Markers, Biological
pubmed:year
1998
pubmed:articleTitle
Müllerian inhibiting substance, alpha-inhibin, and CD99 expression in sex cord-stromal tumors and endometrioid ovarian carcinomas resembling sex cord-stromal tumors.
pubmed:affiliation
Department of Pathology, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't