| pubmed-article:9712028 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9712028 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:9712028 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:9712028 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:9712028 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:9712028 | lifeskim:mentions | umls-concept:C0231174 | lld:lifeskim |
| pubmed-article:9712028 | lifeskim:mentions | umls-concept:C2610891 | lld:lifeskim |
| pubmed-article:9712028 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9712028 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:9712028 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9712028 | pubmed:dateCreated | 1998-8-27 | lld:pubmed |
| pubmed-article:9712028 | pubmed:abstractText | We examined whether IL-2 regulates alloimmune responses by studying allograft survival in wild-type (IL-2+/+) and IL-2 gene-knockout (IL-2-/-) mice. The acute rejection of vascularized, cardiac allografts and the generation of allospecific CTLs were not impaired in the absence of IL-2. In contrast, blocking the B7-CD28 T cell costimulation pathway with CTLA4Ig induced long-term allograft survival (> 100 days) in IL-2+/+ recipients but failed to do so in IL-2-/- mice or in wild-type mice that had been treated with IL-2-neutralizing Ab around the time of transplantation. Allografts rejected by IL-2-/- recipients exhibited extensive mononuclear cell infiltrates despite CTLA4Ig administration. In vivo allostimulation in the absence of IL-2 led to exaggerated T lymphocyte proliferation and impaired apoptosis of activated T cells in untreated and CTLA4Ig-treated mice. These findings indicate that endogenous IL-2 is required for the induction of long-term allograft survival, and that IL-2 regulates alloimmune responses by preparing activated T lymphocytes for alloantigen-induced apoptosis. | lld:pubmed |
| pubmed-article:9712028 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9712028 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9712028 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9712028 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9712028 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9712028 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:9712028 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9712028 | pubmed:author | pubmed-author:DayJJ | lld:pubmed |
| pubmed-article:9712028 | pubmed:author | pubmed-author:BaddouraF KFK | lld:pubmed |
| pubmed-article:9712028 | pubmed:author | pubmed-author:LakkisF GFG | lld:pubmed |
| pubmed-article:9712028 | pubmed:author | pubmed-author:KoniecznyB... | lld:pubmed |
| pubmed-article:9712028 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9712028 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9712028 | pubmed:volume | 161 | lld:pubmed |
| pubmed-article:9712028 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9712028 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9712028 | pubmed:pagination | 1659-63 | lld:pubmed |
| pubmed-article:9712028 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9712028 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9712028 | pubmed:articleTitle | Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice. | lld:pubmed |
| pubmed-article:9712028 | pubmed:affiliation | The Carlos and Marguerite Mason Transplantation Research Center, Emory University and Veterans Affairs Medical Center, Atlanta, GA 30033, USA. | lld:pubmed |
| pubmed-article:9712028 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9712028 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9712028 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:9712028 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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