Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1998-8-27
|
| pubmed:abstractText |
We examined whether IL-2 regulates alloimmune responses by studying allograft survival in wild-type (IL-2+/+) and IL-2 gene-knockout (IL-2-/-) mice. The acute rejection of vascularized, cardiac allografts and the generation of allospecific CTLs were not impaired in the absence of IL-2. In contrast, blocking the B7-CD28 T cell costimulation pathway with CTLA4Ig induced long-term allograft survival (> 100 days) in IL-2+/+ recipients but failed to do so in IL-2-/- mice or in wild-type mice that had been treated with IL-2-neutralizing Ab around the time of transplantation. Allografts rejected by IL-2-/- recipients exhibited extensive mononuclear cell infiltrates despite CTLA4Ig administration. In vivo allostimulation in the absence of IL-2 led to exaggerated T lymphocyte proliferation and impaired apoptosis of activated T cells in untreated and CTLA4Ig-treated mice. These findings indicate that endogenous IL-2 is required for the induction of long-term allograft survival, and that IL-2 regulates alloimmune responses by preparing activated T lymphocytes for alloantigen-induced apoptosis.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
161
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1659-63
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9712028-Animals,
pubmed-meshheading:9712028-Apoptosis,
pubmed-meshheading:9712028-Coronary Circulation,
pubmed-meshheading:9712028-Cytokines,
pubmed-meshheading:9712028-Cytotoxicity, Immunologic,
pubmed-meshheading:9712028-Graft Rejection,
pubmed-meshheading:9712028-Graft Survival,
pubmed-meshheading:9712028-Heart Transplantation,
pubmed-meshheading:9712028-Interleukin-2,
pubmed-meshheading:9712028-Isoantigens,
pubmed-meshheading:9712028-Lymph Nodes,
pubmed-meshheading:9712028-Lymphocyte Activation,
pubmed-meshheading:9712028-Male,
pubmed-meshheading:9712028-Mice,
pubmed-meshheading:9712028-Mice, Inbred BALB C,
pubmed-meshheading:9712028-Mice, Inbred C3H,
pubmed-meshheading:9712028-Mice, Knockout,
pubmed-meshheading:9712028-RNA, Messenger,
pubmed-meshheading:9712028-T-Lymphocytes,
pubmed-meshheading:9712028-T-Lymphocytes, Cytotoxic
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Impaired alloantigen-mediated T cell apoptosis and failure to induce long-term allograft survival in IL-2-deficient mice.
|
| pubmed:affiliation |
The Carlos and Marguerite Mason Transplantation Research Center, Emory University and Veterans Affairs Medical Center, Atlanta, GA 30033, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|