Linked Life Data

9710784

Source:http://linkedlifedata.com/resource/pubmed/id/9710784

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1998-10-28
pubmed:abstractText
To investigate the effects of local corticosteroids during the early inflammatory process in iatrogenically induced surgical wounds, three different types of corticosteroids, dexamethasone sodium phosphate (Decadron), betamethasone sodium phosphate (Celestone Phosphate), and betamethasone sodium phosphate-acetate (Celestone Soluspan), were evaluated using rats. Single doses of corticosteroid were administered locally to male Sprague-Dawley rats after the surgical implantation of a wound chamber, which was used to collect fluid from the surrounding surgical wound. Wound fluids were drawn from the wound chamber at postoperative days 1, 3, and 5 and analyzed for total white blood cells (WBCs) and differential count. In this study, the authors have demonstrated that the corticosteroids (dexamethasone sodium phosphate, betamethasone sodium phosphate, betamethasone sodium phosphate-acetate) cause at least 50% reduction in the total circulating WBCs at the surgical wound site on postoperative day 1, followed by decreased reductions on days 3 and 5.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1067-2516
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
313-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Effect of local corticosteroids on early inflammatory function in surgical wound of rats.
pubmed:affiliation
VA Medical Center, Tucson, AZ 85723, USA.
pubmed:publicationType
Journal Article