| pubmed-article:9701786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9701786 | lifeskim:mentions | umls-concept:C0021359 | lld:lifeskim |
| pubmed-article:9701786 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:9701786 | lifeskim:mentions | umls-concept:C0014180 | lld:lifeskim |
| pubmed-article:9701786 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
| pubmed-article:9701786 | lifeskim:mentions | umls-concept:C0035687 | lld:lifeskim |
| pubmed-article:9701786 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:9701786 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:9701786 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:9701786 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:9701786 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9701786 | pubmed:dateCreated | 1998-10-28 | lld:pubmed |
| pubmed-article:9701786 | pubmed:abstractText | Endometrium is one of the main target tissues of oestrogens. Although homozygous inactivation of oestrogen receptor-alpha leads to infertility in transgenic mice, oestrogen receptor-alpha is detected in endometrium of patients with unexplained infertility. Oestrogen receptor-alpha splicing variants and oestrogen receptor-beta have been studied in oestrogen target tissues, but their expression in endometrium throughout the menstrual cycle and in unexplained infertility is unknown. Using reverse transcription-polymerase chain reaction (RT-PCR), we studied the expression of oestrogen receptor-alpha splicing variants and oestrogen receptor-beta in uterine biopsies from 12 patients with endometriosis and 15 patients with unexplained infertility. A control group included 19 women who had had a previous pregnancy. Our study gave evidence of exon 2, 3, 4 or 7 deleted oestrogen receptor-alpha variants co-existing with the wild-type receptor. We did not find any exon 5 or 6-deleted variants. Exon 4 or 7-deleted variants were detected in all samples. Exon 2 or 3-deleted variants were detected at a similar frequency in fertile women (58 and 68% respectively), endometriotic patients (67 and 83% respectively) and infertile patients (73 and 80% respectively). During the follicular phase, there was a non-significant trend towards a lower frequency of exon-2 deleted variants in the fertile group when compared with the hypofertile group. Oestrogen receptor-beta was detected in all samples. Our preliminary study showed that altered expression of oestrogen receptor-alpha variants and oestrogen receptor-beta may not explain the hypofertility state. | lld:pubmed |
| pubmed-article:9701786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9701786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9701786 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9701786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9701786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9701786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9701786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9701786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9701786 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9701786 | pubmed:issn | 1360-9947 | lld:pubmed |
| pubmed-article:9701786 | pubmed:author | pubmed-author:HedonBB | lld:pubmed |
| pubmed-article:9701786 | pubmed:author | pubmed-author:PujolPP | lld:pubmed |
| pubmed-article:9701786 | pubmed:author | pubmed-author:EdouardEE | lld:pubmed |
| pubmed-article:9701786 | pubmed:author | pubmed-author:MaudelondeTT | lld:pubmed |
| pubmed-article:9701786 | pubmed:author | pubmed-author:ReyJ MJM | lld:pubmed |
| pubmed-article:9701786 | pubmed:author | pubmed-author:DechaudHH | lld:pubmed |
| pubmed-article:9701786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9701786 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:9701786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9701786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9701786 | pubmed:pagination | 641-7 | lld:pubmed |
| pubmed-article:9701786 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
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| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
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| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
| pubmed-article:9701786 | pubmed:meshHeading | pubmed-meshheading:9701786-... | lld:pubmed |
| pubmed-article:9701786 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9701786 | pubmed:articleTitle | Expression of oestrogen receptor-alpha splicing variants and oestrogen receptor-beta in endometrium of infertile patients. | lld:pubmed |
| pubmed-article:9701786 | pubmed:affiliation | Laboratoire de Biologie Cellulaire et Hormonale, CHRU Arnaud de Villeneuve, Montpellier, France. | lld:pubmed |
| pubmed-article:9701786 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9701786 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
