Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1998-8-18
|
| pubmed:abstractText |
Between January 1989 and July 1995 the search for an unrelated donor (UD) was started for 379 consecutive Italian patients with Philadelphia positive (Ph+) chronic myelogenous leukaemia (CML). 89 (23%) were transplanted. The overall probability of transplant before and after December 1991 was 16% and 49%, respectively (P=0.0001), and average interval between search activation and graft was 23 months and 13 months, respectively (P=0.0001). Disease-free survival (DFS) following 60 consecutive transplants performed before February 1996 was 41.5% at 48 months and was 64% for patients grafted after January 1993. In univariate analysis, five variables had a favourable effect on DFS: year of bone marrow transplantation (BMT) after 1993 (P=0.0002), HLA-DRB1 donor/recipient (D/R) match (P=0.0006), total body irradiation (TBI) containing regimen (P=0.0006), graft-versus-host disease (GvHD) prophylaxis including 'early' cyclosporin before the transplant, and a marrow cell dose > 3 x 10(8)/kg of recipient body weight (P=0.04). Multivariate analysis confirmed that HLA identity (P=0.006), TBI-containing regimen (P=0.0001) and 'early cyclosporin' (P=0.04) were associated with higher DFS. Transplant-related mortality (TRM) was 67% in patients grafted before January 1993 and 30% in patients grafted subsequently (P=0.002). Multivariate analysis confirmed DRB1 identity (P=0.03) and TBI-containing regimen (P=0.0005) to be independent factors predictive of low TRM. This suggests that the outcome of patients transplanted from an HLA DRB1 matched donor, after a TBI-containing preparative regimen, is similar to results recently reported in patients transplanted from geno-identical siblings. These results indicate that the search should be initiated at diagnosis for patients < 45 years of age and UD BMT should be considered early in the disease course for those with an available DRB1-matched unrelated donor.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0007-1048
|
| pubmed:author |
pubmed-author:AlessandrinoE PEP,
pubmed-author:AversaFF,
pubmed-author:BacigalupoAA,
pubmed-author:BarbantiMM,
pubmed-author:BuscaAA,
pubmed-author:CostaCC,
pubmed-author:De LaurenziAA,
pubmed-author:Di BartolomeoPP,
pubmed-author:DiniGG,
pubmed-author:GuidiSS,
pubmed-author:La NasaGG,
pubmed-author:LamparelliTT,
pubmed-author:LaninoEE,
pubmed-author:LocatelliFF,
pubmed-author:MajolinoII,
pubmed-author:ManfrediniLL,
pubmed-author:MarencoPP,
pubmed-author:RondelliRR,
pubmed-author:RostiGG,
pubmed-author:SoligoDD
|
| pubmed:issnType |
Print
|
| pubmed:volume |
102
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
544-52
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9695972-Adolescent,
pubmed-meshheading:9695972-Adult,
pubmed-meshheading:9695972-Bone Marrow Transplantation,
pubmed-meshheading:9695972-Child,
pubmed-meshheading:9695972-Disease-Free Survival,
pubmed-meshheading:9695972-Female,
pubmed-meshheading:9695972-Graft Survival,
pubmed-meshheading:9695972-Graft vs Host Disease,
pubmed-meshheading:9695972-Humans,
pubmed-meshheading:9695972-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:9695972-Male,
pubmed-meshheading:9695972-Middle Aged,
pubmed-meshheading:9695972-Recurrence,
pubmed-meshheading:9695972-Registries,
pubmed-meshheading:9695972-Survival Rate,
pubmed-meshheading:9695972-Tissue and Organ Procurement,
pubmed-meshheading:9695972-Transplantation, Homologous,
pubmed-meshheading:9695972-Treatment Outcome
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Unrelated donor marrow transplantation for chronic myelogenous leukaemia.
|
| pubmed:affiliation |
Department of Paediatric Haematology/Oncology, Istituto Giannina Gaslini, Genova, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|