Linked Life Data

9694571

Source:http://linkedlifedata.com/resource/pubmed/id/9694571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6-7
pubmed:dateCreated
1998-10-13
pubmed:abstractText
Three main criteria are required to postulate that a factor has an autocrine action in any cell: presence of receptors and biological effects of the factor; local production which must be regulated by physiological signals and the inhibition of its secretion or action should cause effects opposite to those caused by the exogenous factor. In adrenal cells, transforming growth factor beta1 (TGFbeta1) fulfilled these criteria: 1) Adrenal cells possess TGFbeta1 receptors and this factor regulates the expression of adrenal cell specific genes, including ACTH and angiotensin II (AngII) receptors and several steroidogenic enzymes, leading to changes in the steroidogenic responsiveness; 2) Adrenal cells express and secrete TGFbeta1 and its secretion is regulated by the two adrenal specific hormones ACTH and AngII; 3) The blockade of TGFbeta1 protein synthesis by an antisense oligonucleotide produces changes in adrenal cell functions opposed to those induced by the exogenous factor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0018-5043
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
411-5
pubmed:dateRevised
2009-2-19
pubmed:meshHeading
pubmed:articleTitle
Autocrine role of TGFbeta1 in adrenal.
pubmed:affiliation
INSERM-INRA U418, Hôpital Debrousse, Lyon, France.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't