Linked Life Data

9689727

Source:http://linkedlifedata.com/resource/pubmed/id/9689727

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1998-10-13
pubmed:abstractText
Short-chain fatty acids (SCFA) are produced by microbial fermentation in the hindgut in considerable amounts. Most of the anions in hindgut contents are SCFA, mainly acetate, propionate and butyrate. SCFA are rapidly absorbed. Mechanisms involved in the transepithelial transport are discussed. Besides the contribution to the overall energy metabolism of animals or men, SCFA have a number of further important effects on the colonic mucosa. Factors affecting the pH of compartments in the mucosa, cell swelling, stimulation of mucin release and of mucosal blood flow are mentioned. Controversial reports are known on the role of SCFA in the metabolism of colonocytes. In spite of the conflicting opinions on the interaction between SCFA metabolism and the development of colitis ulcerosa, diverticulosis and colorectal cancer seems to exist. The obscure differences between the effects of SCFA on cell proliferation, differentiation and apoptosis of colonocytes in vivo and in vitro indicate that besides direct effects of SCFA systemic effects such as neural and humoral factors are of crucial importance. The opposing effects of SCFA on proliferation and apoptosis in normal colonocytes and in colonic cancer cells may open possibilities for prevention and/or therapy of patients with colonic diseases.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0165-2176
pubmed:author
pubmed:issnType
Print
pubmed:volume
20 Suppl 3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S52-9
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Role of short-chain fatty acids in the hind gut.
pubmed:affiliation
Department of Physiology, School of Veterinary Medicine, Hannover, Germany. vengelh@physiology.tiho-hannover.de
pubmed:publicationType
Journal Article, Review