Linked Life Data

9687308

Source:http://linkedlifedata.com/resource/pubmed/id/9687308

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1998-9-3
pubmed:abstractText
Laboratory rats generally do not respond reproductively to short days (SD) unless they are given treatments that unmask reproductive inhibition in SD. While young Fischer 344 (F344) rats are unusual among rat strains in that SD substantially inhibit their reproductive response, the inhibition is not as strong as in the classically photoresponsive species. Rats may have two components to photoresponsivenes: 1) an obligate inhibition by SD, and 2) a facultative inhibition in response to biologically relevant challenges. This study tested whether maturing male F344 rats, which clearly have an obligate inhibition of reproduction in SD, also have an additional, facultative inhibition of reproduction in SD in response to food restriction, a biologically reasonable challenge, or to neonatal androgen treatment, a pharmacological treatment that presumably alters organizational events in the development of the reproductive axis. Food restriction over a period of 13 wk strongly enhanced the inhibition of testicular growth by SD. Similarly, testosterone propionate (TP) treatment at 3 days of age strongly enhanced the inhibition of testicular growth by SD. Neonatal TP treatment along with SD inhibited testicular development almost as strongly as that observed in some commonly studied photoresponsive rodents, but for only half as many weeks. Thus, F344 rats possess an obligate inhibition of testicular development in SD that can be enhanced facultatively by food restriction and even more greatly enhanced by neonatal TP treatment. This combination of obligate and facultative responses to SD may have been important to wild rats ancestral to laboratory rats.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0006-3363
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
358-63
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Food and neonatal androgen interact with photoperiod to inhibit reproductive maturation in Fischer 344 rats.
pubmed:affiliation
Biology Department, College of William and Mary, Williamsburg, Virginia 23187-8795, USA. pdheid@facstaff.wm.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't