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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1998-11-4
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pubmed:abstractText |
The single-dose disposition kinetics of danofloxacin were determined in clinically normal lactating cows after intravenous (i.v.) and intramuscular (i.m.) administration of the drug at 1.25 mg/kg. The drug concentrations in blood serum and milk were determined by microbiological assay methods and the data were subjected to kinetic analysis. The mean i.v. and i.m. elimination half-lives (t1/2el) in serum were 54.9 and 135.7 min, respectively. The steady-state volume of distribution (Vss) was 2.04 L/kg. The drug was quickly absorbed after i.m. injection but a 'flip flop' effect was clearly evident and bioavailability was > 100%. Penetration of danofloxacin from blood into milk was rapid and extensive with drug concentrations in milk exceeding those in serum beginning 90-120 min after i.v. and i.m. administration and onwards. Milk danofloxacin concentrations equal to or higher than the minimal inhibitory concentrations (MIC) for pathogenic Gram-negative bacteria and Mycoplasma species were maintained over approximately 24 h. Concentrations greater than the MIC for Staphylococcus aureus were maintained in the milk for 12 h.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
0140-7783
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
21
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
209-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9673962-Animals,
pubmed-meshheading:9673962-Anti-Infective Agents,
pubmed-meshheading:9673962-Area Under Curve,
pubmed-meshheading:9673962-Cattle,
pubmed-meshheading:9673962-Drug Residues,
pubmed-meshheading:9673962-Female,
pubmed-meshheading:9673962-Fluoroquinolones,
pubmed-meshheading:9673962-Gram-Negative Bacteria,
pubmed-meshheading:9673962-Injections, Intramuscular,
pubmed-meshheading:9673962-Injections, Intravenous,
pubmed-meshheading:9673962-Lactation,
pubmed-meshheading:9673962-Milk,
pubmed-meshheading:9673962-Quinolones,
pubmed-meshheading:9673962-Staphylococcus aureus
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pubmed:year |
1998
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pubmed:articleTitle |
Pharmacokinetics and penetration of danofloxacin from the blood into the milk of cows.
|
pubmed:affiliation |
Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, Israel.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|