rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
7
|
pubmed:dateCreated |
1998-8-11
|
pubmed:abstractText |
Thrombocytopenia is often the dose-limiting toxicity for radionuclide therapy. Prediction of platelet counts after therapy is important for treatment planning. Simple prediction methods based on linear correlation between radiation dose and blood count nadir have been insufficient because they have not considered time, because of the complicated hierarchical structure of the hematopoietic system in which platelets are not directly injured by low dose rate radiation and because of changing radiation dose rates to marrow with time. This study addresses these problems using a cell kinetics model.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0161-5505
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
39
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1223-9
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:9669399-Animals,
pubmed-meshheading:9669399-Bone Marrow Cells,
pubmed-meshheading:9669399-Burkitt Lymphoma,
pubmed-meshheading:9669399-Cell Cycle,
pubmed-meshheading:9669399-Copper Radioisotopes,
pubmed-meshheading:9669399-Dose-Response Relationship, Radiation,
pubmed-meshheading:9669399-Heterocyclic Compounds,
pubmed-meshheading:9669399-Humans,
pubmed-meshheading:9669399-Mice,
pubmed-meshheading:9669399-Mice, Nude,
pubmed-meshheading:9669399-Models, Biological,
pubmed-meshheading:9669399-Neoplasm Transplantation,
pubmed-meshheading:9669399-Organometallic Compounds,
pubmed-meshheading:9669399-Radioimmunotherapy,
pubmed-meshheading:9669399-Radiopharmaceuticals,
pubmed-meshheading:9669399-Thrombocytopenia
|
pubmed:year |
1998
|
pubmed:articleTitle |
A preliminary cell kinetics model of thrombocytopenia after radioimmunotherapy.
|
pubmed:affiliation |
Division of Hematology/Oncology, and Radiation Oncology, University of California Davis, Cancer Center, Sacramento, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|