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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-7-23
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pubmed:abstractText |
Cells from patients with Fanconi anemia (FA) show decreased viability and decreased chromosome stability after treatment with DNA cross-linking agents, compared to normal cells. FA cells also show a relative accumulation at the G2/M transition after such treatment. This has suggested a possible checkpoint abnormality. In the studies presented here, treatment with hydroxyurea, caffeine or inhibitors of cell cycle kinases did not reveal abnormalities in survival or chromosome stability in FA-A or FA-D cells. Chromosomal breaks introduced by hydrogen peroxide or methyl methanesulfonate accumulated to the same extent in FA-A or FA-D cells as in normal cells. We conclude that FA-A and FA-D cells respond normally to agents known to alter the cell cycle or introduce DNA strand breaks. FA cells process strand breaks and a variety of DNA monoadducts normally. Our results are compatible with repair of DNA crosslinks being slower in FA than in normal cells and FA cells having normal cell cycle checkpoints.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, Alkylating,
http://linkedlifedata.com/resource/pubmed/chemical/Caffeine,
http://linkedlifedata.com/resource/pubmed/chemical/Central Nervous System Stimulants,
http://linkedlifedata.com/resource/pubmed/chemical/Cross-Linking Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Adducts,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyurea,
http://linkedlifedata.com/resource/pubmed/chemical/Methyl Methanesulfonate,
http://linkedlifedata.com/resource/pubmed/chemical/Mitomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0740-7750
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
371-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9661700-Antibiotics, Antineoplastic,
pubmed-meshheading:9661700-Antineoplastic Agents, Alkylating,
pubmed-meshheading:9661700-Caffeine,
pubmed-meshheading:9661700-Cell Cycle,
pubmed-meshheading:9661700-Cells, Cultured,
pubmed-meshheading:9661700-Central Nervous System Stimulants,
pubmed-meshheading:9661700-Chromosome Breakage,
pubmed-meshheading:9661700-Cross-Linking Reagents,
pubmed-meshheading:9661700-DNA Adducts,
pubmed-meshheading:9661700-Enzyme Inhibitors,
pubmed-meshheading:9661700-Fanconi Anemia,
pubmed-meshheading:9661700-Humans,
pubmed-meshheading:9661700-Hydrogen Peroxide,
pubmed-meshheading:9661700-Hydroxyurea,
pubmed-meshheading:9661700-Methyl Methanesulfonate,
pubmed-meshheading:9661700-Mitomycin,
pubmed-meshheading:9661700-Oxidants
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pubmed:year |
1997
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pubmed:articleTitle |
Fanconi anemia group A and D cell lines respond normally to inhibitors of cell cycle regulation.
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pubmed:affiliation |
Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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