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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1998-7-27
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pubmed:abstractText |
The phenotypically similar hamster mutants irs1 and irs1SF exhibit high spontaneous chromosome instability and broad-spectrum mutagen sensitivity, including extreme sensitivity to DNA cross-linking agents. The human XRCC2 and XRCC3 genes, which functionally complement irs1 and irs1SF, respectively, were previously mapped in somatic cell hybrids. Characterization of these genes and sequence alignments reveal that XRCC2 and XRCC3 are members of an emerging family of Rad51-related proteins that likely participate in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 is shown to interact directly with HsRad51, and like Rad55 and Rad57 in yeast, may cooperate with HsRad51 during recombinational repair. Analysis of the XRCC2 mutation in irs1 implies that XRCC2's function is not essential for viability in cultured hamster cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cross-Linking Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RAD51 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Rad51 Recombinase,
http://linkedlifedata.com/resource/pubmed/chemical/XRCC2 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1097-2765
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pubmed:author |
pubmed-author:AdamsonA WAW,
pubmed-author:BrookmanK WKW,
pubmed-author:ChenD JDJ,
pubmed-author:FanWW,
pubmed-author:JonesN JNJ,
pubmed-author:LamerdinJ EJE,
pubmed-author:LiuNN,
pubmed-author:NarayanaL SLS,
pubmed-author:SchildDD,
pubmed-author:ShehM LML,
pubmed-author:SicilianoM JMJ,
pubmed-author:SorensenK JKJ,
pubmed-author:TebbsR SRS,
pubmed-author:ThompsonL HLH,
pubmed-author:TuckerJ DJD,
pubmed-author:WalterC ACA,
pubmed-author:ZhouZ QZQ
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pubmed:issnType |
Print
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pubmed:volume |
1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
783-93
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9660962-Animals,
pubmed-meshheading:9660962-Base Sequence,
pubmed-meshheading:9660962-Chromosomes,
pubmed-meshheading:9660962-Cricetinae,
pubmed-meshheading:9660962-Cross-Linking Reagents,
pubmed-meshheading:9660962-DNA, Complementary,
pubmed-meshheading:9660962-DNA Damage,
pubmed-meshheading:9660962-DNA-Binding Proteins,
pubmed-meshheading:9660962-Genetic Complementation Test,
pubmed-meshheading:9660962-Genome, Human,
pubmed-meshheading:9660962-HeLa Cells,
pubmed-meshheading:9660962-Humans,
pubmed-meshheading:9660962-Molecular Sequence Data,
pubmed-meshheading:9660962-Precipitin Tests,
pubmed-meshheading:9660962-RNA, Messenger,
pubmed-meshheading:9660962-Rad51 Recombinase,
pubmed-meshheading:9660962-Sequence Homology, Amino Acid,
pubmed-meshheading:9660962-Transformation, Genetic,
pubmed-meshheading:9660962-Yeasts
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pubmed:year |
1998
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pubmed:articleTitle |
XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.
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pubmed:affiliation |
Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94551, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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