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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0060369,
umls-concept:C0086597,
umls-concept:C0205314,
umls-concept:C0439851,
umls-concept:C0524637,
umls-concept:C0599697,
umls-concept:C0679622,
umls-concept:C1333578,
umls-concept:C1514562,
umls-concept:C1552596,
umls-concept:C1705730,
umls-concept:C1879547,
umls-concept:C1947931
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pubmed:issue |
29
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pubmed:dateCreated |
1998-8-13
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pubmed:databankReference |
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pubmed:abstractText |
Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras. Using the yeast two-hybrid protein-protein interaction assay, we show that FRS2/SNT-1 and a newly isolated SNT-2 protein directly bind to FGF receptor-1 (FGFR-1). A juxtamembrane segment of FGFR-1 and the phosphotyrosine-binding domain of SNTs are both necessary and sufficient for interaction in yeast and in vitro, and FGFR-mediated SNT tyrosine phosphorylation in vivo requires these segments of receptor and SNT. Our findings establish SNTs as direct protein links between FGFR-1 and multiple downstream pathways. The SNT binding motif of FGFR-1 is distinct from previously described phosphotyrosine-binding domain recognition motifs, lacking both tyrosine and asparagine residues.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FRS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fgfr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Fibroblast Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Fibroblast Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
273
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17987-90
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9660748-3T3 Cells,
pubmed-meshheading:9660748-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:9660748-Amino Acid Sequence,
pubmed-meshheading:9660748-Animals,
pubmed-meshheading:9660748-Binding Sites,
pubmed-meshheading:9660748-Carrier Proteins,
pubmed-meshheading:9660748-Ligands,
pubmed-meshheading:9660748-Lipoproteins,
pubmed-meshheading:9660748-Membrane Proteins,
pubmed-meshheading:9660748-Mice,
pubmed-meshheading:9660748-Molecular Sequence Data,
pubmed-meshheading:9660748-Molecular Weight,
pubmed-meshheading:9660748-Phosphoproteins,
pubmed-meshheading:9660748-Phosphorylation,
pubmed-meshheading:9660748-Protein Binding,
pubmed-meshheading:9660748-Receptor, Fibroblast Growth Factor, Type 1,
pubmed-meshheading:9660748-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:9660748-Receptors, Fibroblast Growth Factor,
pubmed-meshheading:9660748-Tyrosine
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pubmed:year |
1998
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pubmed:articleTitle |
Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.
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pubmed:affiliation |
Brookdale Center for Developmental and Molecular Biology, Cellular, Biochemical and Developmental Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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