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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1998-9-16
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pubmed:abstractText |
Kindling induced by 13 intraperitoneal injections of 40 mg/kg pentylenetetrazole (PTZ) over a period of 4 weeks resulted in a significant long-lasting increase in both the convulsive susceptibility of animals to the convulsant and the density of the specific [3H]-L-glutamate binding sites in the hippocampus. The quisqualate- and kainate-sensitive [3H]-L-glutamate binding sites were increased 24 h after the final PTZ injection, whereas the N-methyl-D-aspartate (NMDA)-sensitive sites had only a tendency to be enhanced. Furthermore, we investigated [3H]-L-glutamate binding on metabotropic receptors and found a significant increase in the hippocampus following PTZ kindling. In addition, in hippocampal tissue of kindled rats (+/-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (trans-ACPD)-stimulated inositol phosphate formation is increased. It can be concluded that the increase in metabotropic glutamate receptor (mGluR) density may be the expression of a specific enhancement in susceptibility of the glutamatergic systems to this excitatory amino acid developing in the course of PTZ-induced kindling.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-amino-1,3-dicarboxycyclopentane,
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/6-Cyano-7-nitroquinoxaline-2,3-dione,
http://linkedlifedata.com/resource/pubmed/chemical/CGP 39653,
http://linkedlifedata.com/resource/pubmed/chemical/Convulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloleucine,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Pentylenetetrazole,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-4819
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
527-30
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:9655239-2-Amino-5-phosphonovalerate,
pubmed-meshheading:9655239-6-Cyano-7-nitroquinoxaline-2,3-dione,
pubmed-meshheading:9655239-Animals,
pubmed-meshheading:9655239-Brain Chemistry,
pubmed-meshheading:9655239-Convulsants,
pubmed-meshheading:9655239-Cycloleucine,
pubmed-meshheading:9655239-Dizocilpine Maleate,
pubmed-meshheading:9655239-Excitatory Amino Acid Antagonists,
pubmed-meshheading:9655239-Glutamic Acid,
pubmed-meshheading:9655239-Hippocampus,
pubmed-meshheading:9655239-Inositol Phosphates,
pubmed-meshheading:9655239-Kindling, Neurologic,
pubmed-meshheading:9655239-Male,
pubmed-meshheading:9655239-Neuroprotective Agents,
pubmed-meshheading:9655239-Pentylenetetrazole,
pubmed-meshheading:9655239-Radioligand Assay,
pubmed-meshheading:9655239-Rats,
pubmed-meshheading:9655239-Rats, Wistar,
pubmed-meshheading:9655239-Receptors, AMPA,
pubmed-meshheading:9655239-Receptors, Glutamate,
pubmed-meshheading:9655239-Receptors, Kainic Acid,
pubmed-meshheading:9655239-Receptors, Metabotropic Glutamate,
pubmed-meshheading:9655239-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:9655239-Tritium
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pubmed:year |
1998
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pubmed:articleTitle |
Sensitivity and density of glutamate receptor subtypes in the hippocampal formation are altered in pentylenetetrazole-kindled rats.
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pubmed:affiliation |
Institute of Pharmacology and Toxicology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany. helmut.schroeder@medizin.uni-magdeburg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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