| pubmed-article:9653188 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9653188 | lifeskim:mentions | umls-concept:C0003577 | lld:lifeskim |
| pubmed-article:9653188 | lifeskim:mentions | umls-concept:C0004461 | lld:lifeskim |
| pubmed-article:9653188 | lifeskim:mentions | umls-concept:C0026609 | lld:lifeskim |
| pubmed-article:9653188 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:9653188 | lifeskim:mentions | umls-concept:C1948058 | lld:lifeskim |
| pubmed-article:9653188 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:9653188 | lifeskim:mentions | umls-concept:C0056695 | lld:lifeskim |
| pubmed-article:9653188 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:9653188 | lifeskim:mentions | umls-concept:C0443301 | lld:lifeskim |
| pubmed-article:9653188 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:9653188 | pubmed:dateCreated | 1998-8-6 | lld:pubmed |
| pubmed-article:9653188 | pubmed:abstractText | Axonal injury increases intracellular Ca2+ and cAMP and has been shown to induce gene expression, which is thought to be a key event for regeneration. Increases in intracellular Ca2+ and/or cAMP can alter gene expression via activation of a family of transcription factors that bind to and modulate the expression of CRE (Ca2+/cAMP response element) sequence-containing genes. We have used Aplysia motor neurons to examine the role of CRE-binding proteins in axonal regeneration after injury. We report that axonal injury increases the binding of proteins to a CRE sequence-containing probe. In addition, Western blot analysis revealed that the level of ApCREB2, a CRE sequence-binding repressor, was enhanced as a result of axonal injury. The sequestration of CRE-binding proteins by microinjection of CRE sequence-containing plasmids enhanced axon collateral formation (both number and length) as compared with control plasmid injections. These findings show that Ca2+/cAMP-mediated gene expression via CRE-binding transcription factors participates in the regeneration of motor neuron axons. | lld:pubmed |
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| pubmed-article:9653188 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9653188 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9653188 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9653188 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9653188 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:9653188 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:9653188 | pubmed:author | pubmed-author:MooreA NAN | lld:pubmed |
| pubmed-article:9653188 | pubmed:author | pubmed-author:DashP KPK | lld:pubmed |
| pubmed-article:9653188 | pubmed:author | pubmed-author:ThamM NMN | lld:pubmed |
| pubmed-article:9653188 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9653188 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:9653188 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9653188 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9653188 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9653188 | pubmed:pagination | 8339-44 | lld:pubmed |
| pubmed-article:9653188 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:9653188 | pubmed:meshHeading | pubmed-meshheading:9653188-... | lld:pubmed |
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| pubmed-article:9653188 | pubmed:meshHeading | pubmed-meshheading:9653188-... | lld:pubmed |
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| pubmed-article:9653188 | pubmed:meshHeading | pubmed-meshheading:9653188-... | lld:pubmed |
| pubmed-article:9653188 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9653188 | pubmed:articleTitle | Sequestration of cAMP response element-binding proteins by transcription factor decoys causes collateral elaboration of regenerating Aplysia motor neuron axons. | lld:pubmed |
| pubmed-article:9653188 | pubmed:affiliation | Department of Neurobiology and Anatomy, University of Texas-Houston Health Science Center, Houston, TX 77225, USA. pdash@nba19.med.uth.tmc.edu | lld:pubmed |
| pubmed-article:9653188 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9653188 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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