|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
14
|
|
pubmed:dateCreated |
1998-8-6
|
|
pubmed:abstractText |
Axonal injury increases intracellular Ca2+ and cAMP and has been shown to induce gene expression, which is thought to be a key event for regeneration. Increases in intracellular Ca2+ and/or cAMP can alter gene expression via activation of a family of transcription factors that bind to and modulate the expression of CRE (Ca2+/cAMP response element) sequence-containing genes. We have used Aplysia motor neurons to examine the role of CRE-binding proteins in axonal regeneration after injury. We report that axonal injury increases the binding of proteins to a CRE sequence-containing probe. In addition, Western blot analysis revealed that the level of ApCREB2, a CRE sequence-binding repressor, was enhanced as a result of axonal injury. The sequestration of CRE-binding proteins by microinjection of CRE sequence-containing plasmids enhanced axon collateral formation (both number and length) as compared with control plasmid injections. These findings show that Ca2+/cAMP-mediated gene expression via CRE-binding transcription factors participates in the regeneration of motor neuron axons.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-1323238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-1646483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-1647024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-1647242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-1677478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-1679120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-1722759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-1969743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-2141668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-2213027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-2475590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-2521922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-2648946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-2842685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-2875459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-2899448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-5534925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-5548710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-6663341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-7472449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-7638182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-7686379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-7751927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-7773010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-7834742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-7848731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-7958915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8021233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8096376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8097062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8114912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8252624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8261139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8521521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8562090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8735878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8804712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8892336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8893013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-8942955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-9037079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9653188-9122258
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
7
|
|
pubmed:volume |
95
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
8339-44
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Sequestration of cAMP response element-binding proteins by transcription factor decoys causes collateral elaboration of regenerating Aplysia motor neuron axons.
|
|
pubmed:affiliation |
Department of Neurobiology and Anatomy, University of Texas-Houston Health Science Center, Houston, TX 77225, USA. pdash@nba19.med.uth.tmc.edu
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
