Linked Life Data

9652388

Source:http://linkedlifedata.com/resource/pubmed/id/9652388

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-7-28
pubmed:abstractText
The search for intracellular phosphoproteins implicated in the regulation of neuronal differentiation led to the identification of Ulip1, a mammalian protein related to the Caenorhabditis elegans unc-33 gene product [Byk, T., Dobransky, T., Cifuentes-Diaz, C. & Sobel, A. (1996) J. Neurosc. 16, 688-701]. The expression level and phosphorylation pattern of Ulip1 were shown to be strongly regulated during development and neuronal differentiation. We have isolated three additional complete coding sequences for members of the Ulip family in the mouse, Ulips 2-4, all preferentially expressed in the nervous system. Furthermore, two Ulip sequences, Ulips A and Ulips B, could be identified in C. elegans. The Ulip family is highly conserved throughout evolution (more than 96 % for Ulips 1-3 and 92.5 % for Ulip4 between mouse and human) and the various members of the family within a single species display about 75% similarity. Sequence comparisons further reveal several highly similar domains and subdomains, including a 32-amino-acid region highly conserved from a bacterial hydantoinase to human Ulips. Two-dimensional immunoblot analysis of in vitro translated Ulips 1-4 demonstrates the existence, for each Ulip protein, of several, most probably differentially phosphorylated forms, in agreement with the presence of conserved phosphorylation consensus sites within their sequences. The expression of Ulips 1-4 mRNAs is differentially regulated during development and nerve-growth-factor-induced neuronal differentiation of PC12 cells. Our results indicate a differential, possibly complementary role of phosphoproteins of the highly conserved Ulip family in the control of neuronal differentiation, in relation with the development and plasticity of the nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-2956
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
254
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14-24
pubmed:dateRevised
2007-7-23
pubmed:meshHeading
pubmed-meshheading:9652388-Amino Acid Sequence, pubmed-meshheading:9652388-Animals, pubmed-meshheading:9652388-Caenorhabditis elegans Proteins, pubmed-meshheading:9652388-Cell Differentiation, pubmed-meshheading:9652388-Cloning, Molecular, pubmed-meshheading:9652388-Conserved Sequence, pubmed-meshheading:9652388-Gene Expression Regulation, Developmental, pubmed-meshheading:9652388-Helminth Proteins, pubmed-meshheading:9652388-Humans, pubmed-meshheading:9652388-Mice, pubmed-meshheading:9652388-Molecular Sequence Data, pubmed-meshheading:9652388-Muscle Proteins, pubmed-meshheading:9652388-Nerve Growth Factors, pubmed-meshheading:9652388-Nerve Tissue Proteins, pubmed-meshheading:9652388-PC12 Cells, pubmed-meshheading:9652388-Phosphoproteins, pubmed-meshheading:9652388-Phosphorylation, pubmed-meshheading:9652388-Phylogeny, pubmed-meshheading:9652388-RNA, Messenger, pubmed-meshheading:9652388-Rats, pubmed-meshheading:9652388-Sequence Alignment, pubmed-meshheading:9652388-Sequence Analysis, DNA
pubmed:year
1998
pubmed:articleTitle
The Ulip family phosphoproteins--common and specific properties.
pubmed:affiliation
INSERM U440, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't