| pubmed-article:9650755 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9650755 | lifeskim:mentions | umls-concept:C0175677 | lld:lifeskim |
| pubmed-article:9650755 | lifeskim:mentions | umls-concept:C0876934 | lld:lifeskim |
| pubmed-article:9650755 | lifeskim:mentions | umls-concept:C0686721 | lld:lifeskim |
| pubmed-article:9650755 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9650755 | pubmed:dateCreated | 1998-10-15 | lld:pubmed |
| pubmed-article:9650755 | pubmed:abstractText | We examined an autopsy series of 14 children with shaken baby syndrome (SBS) who lacked skull fracture. Evidence of axonal injury was sought using immunohistochemical stains for neurofilament, 68-kDa neurofilament and beta-amyloid precursor protein (betaAPP). BetaAPP-positive axons were present in the cerebral white matter of all cases of SBS but were also present in 6 of 7 children dying of non-traumatic hypoxic ischemic encephalopathy (HIE). Swollen axons were present in 11 of 14 cases of SBS and in 6 of 7 cases of HIE. BetaAPP-positive axons were present in both groups in the midbrain and medulla. The cervical spinal cord in SBS contained betaAPP-positive axons in 7 of 11 cases; 5 of 7 contained swollen axons within the white matter tracts; in 2 immunoreactivity was localized to spinal nerve roots; in all 7 there was a predilection for staining at the glial head of the nerve root. Among cases of HIE, none showed abnormal axons or betaAPP-positive reactivity in the cervical cord white matter. We conclude that cerebral axonal injury is common in SBS, and may be due in part to hypoxic/ischemic injury. Cervical cord injury is also common, and cannot be attributed to HIE. These findings corroborate suggestions that flexion-extension injury about the cervical spinal column may be important in the pathogenesis of SBS. | lld:pubmed |
| pubmed-article:9650755 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9650755 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9650755 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:9650755 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9650755 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:9650755 | pubmed:issn | 0001-6322 | lld:pubmed |
| pubmed-article:9650755 | pubmed:author | pubmed-author:SmithC RCR | lld:pubmed |
| pubmed-article:9650755 | pubmed:author | pubmed-author:HoMM | lld:pubmed |
| pubmed-article:9650755 | pubmed:author | pubmed-author:BeckerLL | lld:pubmed |
| pubmed-article:9650755 | pubmed:author | pubmed-author:ShannonPP | lld:pubmed |
| pubmed-article:9650755 | pubmed:author | pubmed-author:DecuPP | lld:pubmed |
| pubmed-article:9650755 | pubmed:author | pubmed-author:DipO OOO | lld:pubmed |
| pubmed-article:9650755 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9650755 | pubmed:volume | 95 | lld:pubmed |
| pubmed-article:9650755 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9650755 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9650755 | pubmed:pagination | 625-31 | lld:pubmed |
| pubmed-article:9650755 | pubmed:dateRevised | 2007-11-9 | lld:pubmed |
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| pubmed-article:9650755 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9650755 | pubmed:articleTitle | Axonal injury and the neuropathology of shaken baby syndrome. | lld:pubmed |
| pubmed-article:9650755 | pubmed:affiliation | Department of Pediatric Laboratory Medicine, Hospital For Sick Children and University of Toronto, Ontario, Canada. | lld:pubmed |
| pubmed-article:9650755 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9650755 | pubmed:publicationType | Comparative Study | lld:pubmed |
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