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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1998-10-15
|
| pubmed:abstractText |
We examined an autopsy series of 14 children with shaken baby syndrome (SBS) who lacked skull fracture. Evidence of axonal injury was sought using immunohistochemical stains for neurofilament, 68-kDa neurofilament and beta-amyloid precursor protein (betaAPP). BetaAPP-positive axons were present in the cerebral white matter of all cases of SBS but were also present in 6 of 7 children dying of non-traumatic hypoxic ischemic encephalopathy (HIE). Swollen axons were present in 11 of 14 cases of SBS and in 6 of 7 cases of HIE. BetaAPP-positive axons were present in both groups in the midbrain and medulla. The cervical spinal cord in SBS contained betaAPP-positive axons in 7 of 11 cases; 5 of 7 contained swollen axons within the white matter tracts; in 2 immunoreactivity was localized to spinal nerve roots; in all 7 there was a predilection for staining at the glial head of the nerve root. Among cases of HIE, none showed abnormal axons or betaAPP-positive reactivity in the cervical cord white matter. We conclude that cerebral axonal injury is common in SBS, and may be due in part to hypoxic/ischemic injury. Cervical cord injury is also common, and cannot be attributed to HIE. These findings corroborate suggestions that flexion-extension injury about the cervical spinal column may be important in the pathogenesis of SBS.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Protein Precursor,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neurofilament Proteins
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0001-6322
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
95
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
625-31
|
| pubmed:dateRevised |
2007-11-9
|
| pubmed:meshHeading |
pubmed-meshheading:9650755-Amyloid beta-Protein Precursor,
pubmed-meshheading:9650755-Axons,
pubmed-meshheading:9650755-Biological Markers,
pubmed-meshheading:9650755-Brain,
pubmed-meshheading:9650755-Brain Edema,
pubmed-meshheading:9650755-Brain Injuries,
pubmed-meshheading:9650755-Brain Ischemia,
pubmed-meshheading:9650755-Cell Size,
pubmed-meshheading:9650755-Cerebral Hemorrhage,
pubmed-meshheading:9650755-Child, Preschool,
pubmed-meshheading:9650755-Child Abuse,
pubmed-meshheading:9650755-Humans,
pubmed-meshheading:9650755-Hypoxia, Brain,
pubmed-meshheading:9650755-Infant,
pubmed-meshheading:9650755-Infant, Newborn,
pubmed-meshheading:9650755-Nerve Tissue Proteins,
pubmed-meshheading:9650755-Neurofilament Proteins,
pubmed-meshheading:9650755-Retrospective Studies,
pubmed-meshheading:9650755-Spinal Cord,
pubmed-meshheading:9650755-Spinal Cord Injuries,
pubmed-meshheading:9650755-Spinal Nerve Roots,
pubmed-meshheading:9650755-Stress, Mechanical,
pubmed-meshheading:9650755-Syndrome,
pubmed-meshheading:9650755-Whiplash Injuries
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Axonal injury and the neuropathology of shaken baby syndrome.
|
| pubmed:affiliation |
Department of Pediatric Laboratory Medicine, Hospital For Sick Children and University of Toronto, Ontario, Canada.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|