rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1998-7-20
|
pubmed:abstractText |
On the basis of cyclodextrin, 6-selenium bridged beta-cyclodextrin (6-beta-CD-Se-Se-beta-CD, known as 6-SeCD) was synthesized by the selective tosylation of beta-cyclodextrin and nucleophilic displacement by sodium hydroselenide to imitate glutathione peroxidase (GPX). The GPX activity of diselenide 6-SeCD is 4.3 times that of PZ51. The structure of the mimic 6-SeCD was characterized by means of laser mass spectroscopy, elemental analysis, IR and 1H NMR. The selenium content and its valence in 6-SeCD were determined by means of X-ray photoelectron spectra. Kinetics of the mimic showed that its enzymatic behavior was similar to that of native GPX.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0006-291X
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright 1998 Academic Press.
|
pubmed:issnType |
Print
|
pubmed:day |
18
|
pubmed:volume |
247
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
397-400
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:9642139-Bridged Compounds,
pubmed-meshheading:9642139-Cyclodextrins,
pubmed-meshheading:9642139-Glutathione Peroxidase,
pubmed-meshheading:9642139-Kinetics,
pubmed-meshheading:9642139-Models, Chemical,
pubmed-meshheading:9642139-Molecular Structure,
pubmed-meshheading:9642139-Selenium,
pubmed-meshheading:9642139-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:9642139-beta-Cyclodextrins
|
pubmed:year |
1998
|
pubmed:articleTitle |
Artificial imitation of glutathione peroxidase with 6-selenium-bridged beta-cyclodextrin.
|
pubmed:affiliation |
The National Laboratory of Enzyme Engineering, Jilin University, Changchun, 130023, P.R. China.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|