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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0061878,
umls-concept:C0080202,
umls-concept:C0085358,
umls-concept:C0229664,
umls-concept:C0237401,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1549781,
umls-concept:C1706438,
umls-concept:C1879547,
umls-concept:C2698600
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pubmed:issue |
3
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pubmed:dateCreated |
1998-7-7
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pubmed:abstractText |
Granzyme B (GrB) has been implicated in induction of apoptosis in target cells. The presence of GrB in peripheral blood CD8+ T cells from healthy individuals was analysed in immunocytochemical and flow cytometric studies. Furthermore, CD8+ GrB- T cells and CD8+ GrB+ T cells were compared regarding phenotypical characteristics and susceptibility to both spontaneous and Fasmediated apoptosis. GrB was expressed by approximately one-fifth of CD8+ T cells. Compared with the CD8+ GrB- T-cell subset, the CD8+ GrB+ T-cell subset contained cells that were relatively more activated and more prone to spontaneous apoptosis. Culturing of cells with immunoglobulin M (IgM) anti-Fas monoclonal antibody had no additional effect on the number of CD8+ GrB+ T cells undergoing apoptosis. We suggest that the presence of CD8+ GrB+ T cells in peripheral blood from healthy individuals results from immune surveillance or contact with infectious agents, and that spontaneous apoptosis of these cells might serve as a mechanism for their eventual clearance.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-1371242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-1385530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-1703210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-2111862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-2143580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-2457622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-2584937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-3052628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-3261871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-3904772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-7530337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-7534135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-7540069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-7556064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-7595224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-7697916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-7734048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-7738173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-7945773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8068938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8088328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8103068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8137431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8144943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8251751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8340752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8381831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8383716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8466628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8621891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8690919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8805273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-8861900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9640249-9071329
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
383-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9640249-Antibodies, Monoclonal,
pubmed-meshheading:9640249-Antigens, CD95,
pubmed-meshheading:9640249-Apoptosis,
pubmed-meshheading:9640249-CD8-Positive T-Lymphocytes,
pubmed-meshheading:9640249-Cells, Cultured,
pubmed-meshheading:9640249-Flow Cytometry,
pubmed-meshheading:9640249-Granzymes,
pubmed-meshheading:9640249-Humans,
pubmed-meshheading:9640249-Immunohistochemistry,
pubmed-meshheading:9640249-Lymphocyte Activation,
pubmed-meshheading:9640249-Lymphocyte Subsets,
pubmed-meshheading:9640249-Serine Endopeptidases
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pubmed:year |
1998
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pubmed:articleTitle |
The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells.
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pubmed:affiliation |
Renal Transplant Unit, Academic Medical Center, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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