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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
1998-8-6
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pubmed:abstractText |
The intracellular signals governing cellular proliferation and developmental progression during lymphocyte development are incompletely understood. The tyrosine kinase Blk is expressed preferentially in the B lineage, but its function in B cell development has been largely unexplored. We have generated transgenic mice expressing constitutively active Blk [Blk(Y495F)] in the B and T lymphoid compartments. Expression of Blk(Y495F) in the B lineage at levels similar to that of endogenous Blk induced B lymphoid tumors of limited clonality, whose phenotypes are characteristic of B cell progenitors at the proB/preB-I to preB-II transition. Expression of constitutively active Blk in the T lineage resulted in the appearance of clonal, thymic lymphomas composed of intermediate single positive cells. Taken together, these results indicate that specific B and T cell progenitor subsets are preferentially susceptible to transformation by Blk(Y495F) and suggest a role for Blk in the control of proliferation during B cell development.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-1334460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-1461647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-1503755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-1508213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-1537861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-1579166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-1708890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-1827140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-1900081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-2143520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-2524380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-2966738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-6291785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7513723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7522230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7524079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7526894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7584145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7585947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7596413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7608542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7650487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7662097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7822795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7903854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7905740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-7926785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-8034332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-8156589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-8166770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-8226767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-8381210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-8385609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-8430336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-8700903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9636152-8756343
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
95
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7351-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9636152-Animals,
pubmed-meshheading:9636152-B-Lymphocytes,
pubmed-meshheading:9636152-Cell Division,
pubmed-meshheading:9636152-Cell Transformation, Neoplastic,
pubmed-meshheading:9636152-Clone Cells,
pubmed-meshheading:9636152-Enzyme Activation,
pubmed-meshheading:9636152-Gene Expression,
pubmed-meshheading:9636152-Gene Rearrangement,
pubmed-meshheading:9636152-Hematopoietic Stem Cells,
pubmed-meshheading:9636152-Mice,
pubmed-meshheading:9636152-Mice, Nude,
pubmed-meshheading:9636152-Mice, Transgenic,
pubmed-meshheading:9636152-Phosphorylation,
pubmed-meshheading:9636152-T-Lymphocytes,
pubmed-meshheading:9636152-Transgenes,
pubmed-meshheading:9636152-Tyrosine,
pubmed-meshheading:9636152-src-Family Kinases
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pubmed:year |
1998
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pubmed:articleTitle |
Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase.
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pubmed:affiliation |
Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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