Linked Life Data

9635746

Source:http://linkedlifedata.com/resource/pubmed/id/9635746

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-8-24
pubmed:abstractText
The cyclic lipodepsipeptide, syringomycin E, when incorporated into planar lipid bilayer membranes, forms two types of channels (small and large) that are different in conductance by a factor of sixfold. To discriminate between a cluster organization-type channel structure and other possible different structures for the two channel types, their ionic selectivity and pore size were determined. Pore size was assessed using water-soluble polymers. Ion selectivity was found to be essentially the same for both the small and large channels. Their reversal (zero current) potentials with the sign corresponding to anionic selectivity did not differ by more than 3 mV at a twofold electrolyte gradient across the bilayer. Reduction in the single-channel conductance induced by poly(ethylene glycol)s of different molecular weights demonstrated that the aqueous pore sizes of the small and large channels did not differ by more than 2% and were close to 1 nm. Based on their virtually identical selectivity and size, we conclude that large syringomycin E channels are clusters of small ones exhibiting synchronous opening and closing.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-1384601, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-16665211, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-1696511, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-1719158, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-2413212, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-2441065, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-2462450, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-2573393, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-3225479, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-3968757, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-7679295, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-8558589, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-8589416, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-8783071, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-8825527, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-9050902, http://linkedlifedata.com/resource/pubmed/commentcorrection/9635746-9156580
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0006-3495
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2918-25
pubmed:dateRevised
2010-9-13
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Cluster organization of ion channels formed by the antibiotic syringomycin E in bilayer lipid membranes.
pubmed:affiliation
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104-3308, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't