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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1998-8-24
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pubmed:abstractText |
The effect of citrate and pyrophosphate on the stability of calcium oxalate dihydrate (COD) was studied in an aqueous solution over 7 days. COD was precipitated from 1.0 x 10(-2) mol/l calcium oxalate solution with the addition of citrate and/or pyrophosphate and separated by centrifugation immediately, 48 h and 7 days after the precipitation. The percentage of COD in the precipitate, determined by X-ray diffraction, increased with a rise in citrate or pyrophosphate concentration and reached > or =90% at a citrate concentration of 1.0 x 10(-3) mol/l or a pyrophosphate concentration of 2.0 x 10(-4) mol/l. The resulting COD was completely transformed into calcium oxalate monohydrate within 48 h when the precipitate was composed of <90% COD. Nearly pure COD produced with pyrophosphate was stable over 7 days while that with citrate underwent partial transformation within 48 h. An additive effect of citrate and pyrophosphate was found on the stability of COD. It was concluded that a pyrophosphate concentration above a critical point was sufficient to prevent solution-mediated transformation of COD, and this critical point might be lowered to the physiological range with the presence of citrate.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0300-5623
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
83-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:9631939-Calcium Oxalate,
pubmed-meshheading:9631939-Chemical Precipitation,
pubmed-meshheading:9631939-Citric Acid,
pubmed-meshheading:9631939-Crystallization,
pubmed-meshheading:9631939-Diphosphates,
pubmed-meshheading:9631939-Drug Stability,
pubmed-meshheading:9631939-Humans,
pubmed-meshheading:9631939-Microscopy, Electron, Scanning,
pubmed-meshheading:9631939-Particle Size,
pubmed-meshheading:9631939-Solutions,
pubmed-meshheading:9631939-Urinary Calculi,
pubmed-meshheading:9631939-X-Ray Diffraction
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pubmed:year |
1998
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pubmed:articleTitle |
Effect of citrate and pyrophosphate on the stability of calcium oxalate dihydrate.
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pubmed:affiliation |
Department of Urology, Jichi Medical School, Tochigi-ken, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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