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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1998-6-10
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pubmed:abstractText |
The universal response of vein grafts after insertion into the arterial circulation is the development of intimal hyperplasia; smooth muscle cell proliferation and connective tissue deposition, which may be modulated in part by dysfunctional endothelial nitric oxide (NO) metabolism. This study examines the effects of single dose, local application by pluronic gel of a NO donor, S-nitroso-N-acetylpenicillamine (SNAP) and an NO synthase inhibitor nitro-L-arginine methyl ester (L-NAME) on the formation of intimal hyperplasia.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1078-5884
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
279-89
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:9610339-Animals,
pubmed-meshheading:9610339-Carotid Artery, Common,
pubmed-meshheading:9610339-Cell Division,
pubmed-meshheading:9610339-Cells, Cultured,
pubmed-meshheading:9610339-Collagen,
pubmed-meshheading:9610339-Cytoplasm,
pubmed-meshheading:9610339-Endothelium, Vascular,
pubmed-meshheading:9610339-Female,
pubmed-meshheading:9610339-Hyperplasia,
pubmed-meshheading:9610339-Microscopy, Electron, Scanning,
pubmed-meshheading:9610339-Muscle, Smooth, Vascular,
pubmed-meshheading:9610339-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:9610339-Penicillamine,
pubmed-meshheading:9610339-Rabbits,
pubmed-meshheading:9610339-Vascular Patency,
pubmed-meshheading:9610339-Veins
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pubmed:year |
1998
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pubmed:articleTitle |
Local effects of nitric oxide supplementation and suppression in the development of intimal hyperplasia in experimental vein grafts.
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pubmed:affiliation |
Department of Surgery, Duke University Medical Center, North Carolina 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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