Linked Life Data

9603502

Source:http://linkedlifedata.com/resource/pubmed/id/9603502

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1998-6-2
pubmed:abstractText
Recent work from Riddle and coworkers has shown that in the free-living soil nematode, Caenorhabditis elegans, the decision to become a developmentally arrested, dispersal form known as the dauer ("enduring") larva is controlled, at least in part, by transcription of a wild-type allele at the daf-7 locus. daf-7 mutants are "constitutive dauers." Using this model as a general paradigm for nematode development, I propose that many nematode parasites behave as though they were daf-7 mutants. This will ensure developmental arrest at the L3 stage. I further propose that these organisms obtain the daf-7 gene product required for reentry into the developmental pathway from the mammalian host and that their tissue localization is dictated by the daf-7 homologue that is uniquely recognized by the cognate receptor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-4894
pubmed:author
pubmed:issnType
Print
pubmed:volume
89
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
140-2
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
A hypothesis for the tissue specificity of nematode parasites.
pubmed:affiliation
Department of Pathology, University of Connecticut Health Center, Farmington 06030-3105, USA. rajan@cortex.uchc.edu
pubmed:publicationType
Journal Article, Review