Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1998-6-18
|
| pubmed:abstractText |
A family is described with three-generation transmission of factor V Leiden (a thrombophilic mutation that causes resistance to activated protein C). Legg-Perthes disease developed in three siblings in this family. The male proband and his sister were heterozygous for the mutation and had unilateral hip disease at age 2 years. The brother, who had bilateral hip disease, was homozygous. This novel family provides compelling evidence for the pathoetiologic role of familial thrombophilia in Legg-Perthes disease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0022-3476
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
132
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
885-8
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:9602208-Adult,
pubmed-meshheading:9602208-Child,
pubmed-meshheading:9602208-Child, Preschool,
pubmed-meshheading:9602208-Factor V,
pubmed-meshheading:9602208-Female,
pubmed-meshheading:9602208-Heterozygote,
pubmed-meshheading:9602208-Homozygote,
pubmed-meshheading:9602208-Humans,
pubmed-meshheading:9602208-Legg-Calve-Perthes Disease,
pubmed-meshheading:9602208-Male,
pubmed-meshheading:9602208-Middle Aged,
pubmed-meshheading:9602208-Mutation,
pubmed-meshheading:9602208-Pedigree,
pubmed-meshheading:9602208-Protein C
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Legg-Perthes disease in three siblings, two heterozygous and one homozygous for the factor V Leiden mutation.
|
| pubmed:affiliation |
Division of Hematology/Oncology, Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|