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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1998-7-17
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pubmed:abstractText |
We examined the role of receptor-operated Ca2+ influx in endothelin-1 (ET-1)- or sarafotoxin S6c (S6c)-induced contraction of the muscularis mucosae. Responses of the esophageal muscularis mucosae isolated from guinea-pigs were recorded by an isotonic transducer and a polygraph. ET-1 and S6c produced contraction of the esophageal muscularis mucosae in a concentration-dependent manner. The contractile responses to ETs were abolished in a Ca(2+)-free EGTA-containing medium, weakly inhibited by nicardipine, and markedly inhibited by SK&F96365. In addition, both H-7 and U-73122 strongly inhibited the ET-induced contractions, but U-73343 weakly inhibited these responses. These results indicate that the esophageal muscularis mucosae of guinea pigs has ET receptors that are coupled mainly to receptor-operated Ca2+ influx and linked with the phospholipase C-protein kinase C pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(5-Isoquinolinesulfonyl)-2-Methylp...,
http://linkedlifedata.com/resource/pubmed/chemical/1-(6-((3-methoxyestra-1,3,5(10)-trie...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Estrenes,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidinones,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Endothelin,
http://linkedlifedata.com/resource/pubmed/chemical/Type C Phospholipases,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Viper Venoms,
http://linkedlifedata.com/resource/pubmed/chemical/sarafotoxins s6
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pubmed:status |
MEDLINE
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pubmed:issn |
0160-2446
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31 Suppl 1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S504-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9595525-1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine,
pubmed-meshheading:9595525-Animals,
pubmed-meshheading:9595525-Calcium,
pubmed-meshheading:9595525-Endothelin-1,
pubmed-meshheading:9595525-Endothelins,
pubmed-meshheading:9595525-Enzyme Inhibitors,
pubmed-meshheading:9595525-Esophagus,
pubmed-meshheading:9595525-Estrenes,
pubmed-meshheading:9595525-Guinea Pigs,
pubmed-meshheading:9595525-Male,
pubmed-meshheading:9595525-Muscle, Smooth,
pubmed-meshheading:9595525-Muscle Contraction,
pubmed-meshheading:9595525-Pyrrolidinones,
pubmed-meshheading:9595525-Receptors, Endothelin,
pubmed-meshheading:9595525-Type C Phospholipases,
pubmed-meshheading:9595525-Vasoconstrictor Agents,
pubmed-meshheading:9595525-Viper Venoms
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pubmed:year |
1998
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pubmed:articleTitle |
The role of receptor-operated CA2+ influx in endothelin-induced contraction of the muscularis mucosae.
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pubmed:affiliation |
Department of Pharmacology, Dokkyo University School of Medicine, Tochigi, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro
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