Linked Life Data

9592197

Source:http://linkedlifedata.com/resource/pubmed/id/9592197

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1998-7-22
pubmed:abstractText
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases which catalyse degradation of diverse substrates in the extracellular matrix. The family can be loosely divided into 4 subgroups, i.e., interstitial collagenases, gelatinases, stromelysins and membrane-type MMPs. Data from model systems suggest that MMPs are involved in both stimulating tumor cell growth and promoting invasion and metastasis. Consistent with their role in tumor progression, high levels of certain MMPs have been shown to correlate with poor prognosis in different human cancers. Inhibitors of MMPs prevent or decrease tumor progression in model systems and are currently undergoing evaluation for the treatment of human cancers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1019-6439
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1343-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Matrix metalloproteinases in cancer: prognostic markers and targets for therapy (review).
pubmed:affiliation
Department of Nuclear Medicine and Education and Research Centre, St Vincent's Hospital, Dublin 4, Ireland.
pubmed:publicationType
Journal Article, Review